Han J S, Kwon H S, Yim J B, Hwang D S
Institute for Molecular Biology and Genetics, Seoul National University, Korea.
Mol Gen Genet. 1998 Oct;259(6):610-4. doi: 10.1007/s004380050854.
The E. coli nrd operon contains the genes encoding the two subunits of ribonucleoside diphosphate reductase. We found that the IciA protein binds specifically to the AT-rich upstream region of nrd promoter. In vivo overexpression of IciA increases the expression of nrd gene by four- to five-fold, suggesting that IciA functions as a transcriptional activator for the nrd gene.
大肠杆菌的nrd操纵子包含编码核糖核苷二磷酸还原酶两个亚基的基因。我们发现IciA蛋白特异性结合nrd启动子富含AT的上游区域。体内过表达IciA可使nrd基因的表达增加4至5倍，这表明IciA作为nrd基因的转录激活因子发挥作用。
