Davidson A R, Rojas-Bueno A, Thompson R P, Williams R
Scand J Gastroenterol. 1976;11(6):623-8.
A rapid increase of predominantly unconjugated bilirubin in the blood -- which was not due to haemolysis -- was observed in 38 of 60 patients who had taken an overdose of paracetamol. Studies in the rat given an overdose of the drug showed that within 24 hours there was a striking reduction in the activity of bilirubin glucuronyl-transferase and the content of cytochrome P.450 in the liver. It is suggested that such early damage of the hepatic endoplasmic reticulum contributes to the hyperbilirubinaemia of paracetamol poisoning.
在60例过量服用对乙酰氨基酚的患者中，有38例出现血液中主要为非结合胆红素的快速增加，且并非由溶血所致。对过量服用该药物的大鼠进行的研究表明，24小时内肝脏中胆红素葡萄糖醛酸基转移酶的活性和细胞色素P450的含量显著降低。有人认为，肝内质网的这种早期损伤促成了对乙酰氨基酚中毒的高胆红素血症。
