Akopian G V
Stomatologiia (Mosk). 1998;77(5):4-7.
The aim of our investigations was to elucidate some immune aspects of combination of caries and periodontitis with periodic disease (PD), also known as familial Mediterranean fever. In this regard in patients with active and non-active stage of PD we have studied dynamic changes of concentration of secretory immunoglobulin A (SIgA) in saliva and phagocytic activity of neutrophils derived from gum blood. It has been shown that in patients with PD these indices of local immunity of oral cavity had tendency to a decrease especially in case of PD and periodontitis combination. Disturbances of local immunity was significant in active stage of PD. Based on the obtained data and analysis of latest literature data we suppose that above mentioned changes in local immunity depended on the exhaustion of adaptive properties of patients' local immunity more pronounced in case of chronic inflammation and infection foci formation in oral cavity.
我们研究的目的是阐明龋齿和牙周炎与周期性疾病（PD）（也称为家族性地中海热）合并存在时的一些免疫方面。在这方面，我们对处于PD活动期和非活动期的患者，研究了唾液中分泌型免疫球蛋白A（SIgA）浓度的动态变化以及牙龈血中中性粒细胞的吞噬活性。结果表明，PD患者口腔局部免疫的这些指标有下降趋势，尤其是在PD与牙周炎合并存在的情况下。局部免疫紊乱在PD活动期很明显。基于所获得的数据以及对最新文献数据的分析，我们推测上述局部免疫的变化取决于患者局部免疫适应性的耗竭，在口腔出现慢性炎症和感染灶时更为明显。
