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[肾移植术后患者下肢反射性交感神经营养不良综合征——环孢素A治疗的又一并发症?]

[The reflex sympathetic dystrophy syndrome of the lower extremities in patients after kidney transplantation--another complication of cyclosporin A therapy?].

作者信息

Grandtnerová B, Lepej J, Marková I, Spisiaková D

机构信息

Transplantacné centrum, NsP F. D. Roosevelta, Banská Bystrica.

出版信息

Vnitr Lek. 1998 Feb;44(2):93-7.

PMID:9820083
Abstract

The authors describe a new complication observed in patients after transplantation of the kidneys, characterized by intensive periarticular pain of the joints of the lower extremities, mostly with a symmetrical affection of the heels and knees, associated with vasomotor changes in the affected area, X-ray evidence of patchy osteoporosis and an increased periarticular activity of radionuclide on bone scans. The symptoms develop shortly after transplantation and recede within several months. The clinical findings, X-ray and scintigraphic changes are typical for the syndrome of reflex sympathetic dystrophy. The etiology of the syndrome remains obscure, the symptomatology recedes parallel with reduction of the dosage and levels of cyclosporin A.

摘要

作者描述了一种在肾移植患者中观察到的新并发症,其特征为下肢关节周围剧痛,主要累及足跟和膝关节且多为对称性,伴有受累区域的血管舒缩变化、X线显示斑片状骨质疏松以及骨扫描时关节周围放射性核素活性增加。症状在移植后不久出现,并在数月内消退。临床发现、X线及闪烁扫描变化符合反射性交感神经营养不良综合征。该综合征的病因仍不清楚,其症状随着环孢素A剂量和血药浓度的降低而逐渐消退。

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