寻常型银屑病泰国患者中HLA I类和II类等位基因的血清学及分子分析

Serological and molecular analysis of HLA class I and II alleles in Thai patients with psoriasis vulgaris.

作者信息

Vejbaesya S, Eiermann T H, Suthipinititharm P, Bancha C, Stephens H A, Luangtrakool K, Chandanayingyong D

机构信息

Department of Transfusion Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Tissue Antigens. 1998 Oct;52(4):389-92. doi: 10.1111/j.1399-0039.1998.tb03061.x.

DOI:10.1111/j.1399-0039.1998.tb03061.x

PMID:9820604

Abstract

The HLA class I and class II alleles in 67 patients with type I psoriasis vulgaris, 23 patients with type II psoriasis vulgaris and 140 healthy individuals were analyzed. The frequencies of HLA-A2, -B46, -B57 and DQB10303 were significantly increased in type I psoriasis compared to the controls (Pc<0.05). Molecular analysis of HLA-A2 alleles showed an increase in HLA-A0207 and a decrease in HLA-A0203 in type I psoriasis. HLA-DQB10301 was significantly decreased in type I psoriasis compared to the normal controls (Pc<0.05). No association of any alleles with type II psoriasis was observed. This data demonstrated two susceptible haplotypes: HLA-A1-B57-DRB10701-DQA10201-DQB10303 (AH57.1) and HLA-A2-B46-DRB10901-DQA10301-DQB10303 (AH46.1) for type I psoriasis in the Thai population. Besides, the haplotype AH46.1 was also associated with type II psoriasis.

摘要

对67例寻常型Ⅰ型银屑病患者、23例寻常型Ⅱ型银屑病患者及140名健康个体的HLAⅠ类和Ⅱ类等位基因进行了分析。与对照组相比，寻常型Ⅰ型银屑病患者中HLA - A2、- B46、- B57和DQB10303的频率显著升高（Pc<0.05）。对HLA - A2等位基因的分子分析显示，寻常型Ⅰ型银屑病中HLA - A0207增加，HLA - A0203减少。与正常对照组相比，寻常型Ⅰ型银屑病中HLA - DQB10301显著降低（Pc<0.05）。未观察到任何等位基因与寻常型Ⅱ型银屑病有关联。该数据表明，在泰国人群中，寻常型Ⅰ型银屑病存在两种易感单倍型：HLA - A1 - B57 - DRB10701 - DQA10201 - DQB10303（AH57.1）和HLA - A2 - B46 - DRB10901 - DQA10301 - DQB10303（AH46.1）。此外，单倍型AH46.1也与寻常型Ⅱ型银屑病有关联。