Saad W A, de Arruda Camargo L A, Antunes-Rodrigues J, Simões S
Department of Physiology, School of Dentistry, Paulista State University, Araraquara, SP, Brazil.
Brain Res Bull. 1998 Sep 15;47(2):163-9. doi: 10.1016/s0361-9230(98)00057-4.
Water and sodium chloride intake was studied in male Holtzman rats weighing 250-300 g that had been subjected to electrolytic and chemical lesions of the septal area (SA). Water intake increased in animals with electrolytic lesion of the SA bilaterally from 169.37+/-8.55 (sham) to 214.87+/-23.10 ml/5 days (lesioned). Water intake decreased after ibotenic acid lesion of the SA from 229.33+/-27.60 to 127.33+/-22.84 ml/5 days. Sodium chloride intake (1.5%) increased in animals with electrolytic lesion of the SA from 10.0+/-1.73 to 15.5+/-1.95 ml/5 days after lesion. Also sodium chloride (1.5%) intake increased after ibotenic acid injection into the SA to a greater extent (from 7.83+/-1.25 to 14.33+/-1.87 ml/5 days). The results indicate that the water intake response may be due to lesions that involve cell bodies and fibers of passage and that the sodium intake response can also be induced by lesions which involve only cell bodies. Finally, these results led us to conclude that the SA uses its cell bodies and afferent bodies and fibers for processing inputs mediating water intake and salt appetite and that the cells bodies of the SA are implicated in increased water intake.
对体重250 - 300克的雄性霍尔兹曼大鼠进行了水和氯化钠摄入量的研究，这些大鼠的隔区（SA）已遭受电解和化学损伤。双侧SA电解损伤的动物的水摄入量从169.37±8.55（假手术组）增加到214.87±23.10毫升/5天（损伤组）。SA经鹅膏蕈氨酸损伤后，水摄入量从229.33±27.60降至127.33±22.84毫升/5天。SA电解损伤的动物的氯化钠摄入量（1.5%）在损伤后从10.0±1.73增加到15.5±1.95毫升/5天。同样，向SA注射鹅膏蕈氨酸后，氯化钠（1.5%）摄入量增加幅度更大（从7.83±1.25增加到14.33±1.87毫升/5天）。结果表明，水摄入量的反应可能是由于涉及细胞体和传导纤维的损伤，而钠摄入量的反应也可由仅涉及细胞体的损伤诱导。最后，这些结果使我们得出结论，SA利用其细胞体、传入体和纤维来处理介导水摄入和盐食欲的输入信息，并且SA的细胞体与水摄入量增加有关。
