• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TRH-like immunoreactivity in urine, serum and extrahypothalamic brain: non-identity with synthetic pyroglu-hist-pro-NH2 (TRH).

作者信息

Youngblood W W, Lipton M A, Kizer J S

出版信息

Brain Res. 1978 Jul 28;151(1):99-116. doi: 10.1016/0006-8993(78)90953-8.

DOI:10.1016/0006-8993(78)90953-8
PMID:98209
Abstract

TRH-like immunoreactive substances obtained from several areas of rat brain and from human serum and urine were chromatographically separated by TLC and the resulting immunoreactive 'elution profiles' compared with that obtained for pyroglu-hist-pro-NH2 (TRH). For hypothalamus and septal-preoptic samples TRH was present, but represented less than 100% of the immunoreactive substances. For cortex, amygdala, brain stem, serum and urine, no TRH was detectable in the immunoreactive substances from those samples. The implications of these findings in relation to 'TRH' distribution studies and validation of small peptide RIAs are discussed.

摘要

相似文献

1
TRH-like immunoreactivity in urine, serum and extrahypothalamic brain: non-identity with synthetic pyroglu-hist-pro-NH2 (TRH).
Brain Res. 1978 Jul 28;151(1):99-116. doi: 10.1016/0006-8993(78)90953-8.
2
Thyrotropin-releasing hormone-like bioactivity in placenta: evidence for the existence of substances other than Pyroglu-His-Pro-NH2 (TRH) capable of stimulating pituitary thyrotropin release.
Endocrinology. 1980 Feb;106(2):541-6. doi: 10.1210/endo-106-2-541.
3
TRH-like immunoreactivity in rat pancreas and eye, bovine and sheep pineals, and human placenta: non-identify with synthetic Pyroglu-His-Pro-NH2 (TRH).大鼠胰腺和眼睛、牛和羊松果体以及人胎盘中的促甲状腺激素释放激素样免疫反应性：与合成的焦谷氨酸-组氨酸-脯氨酸-酰胺（促甲状腺激素释放激素）不同。
Brain Res. 1979 Mar 9;163(1):101-10. doi: 10.1016/0006-8993(79)90154-9.
4
Urinary excretion of the TRH-like peptide pyroglutamyl-glutamyl-prolineamide in rats.大鼠中促甲状腺激素释放激素样肽焦谷氨酰-谷氨酰-脯氨酰胺的尿排泄情况。
J Endocrinol. 1997 Jun;153(3):411-21. doi: 10.1677/joe.0.1530411.
5
Identification and characterization of thyrotropin-releasing hormone precursor peptides in rat brain.大鼠脑中促甲状腺激素释放激素前体肽的鉴定与表征
Endocrinology. 1987 Jul;121(1):108-15. doi: 10.1210/endo-121-1-108.
6
High serum levels of the thyrotropin-releasing hormone-like peptide pyroglutamyl-glutamyl-prolineamide in patients with carcinoid tumors.
J Clin Endocrinol Metab. 1996 Aug;81(8):2816-20. doi: 10.1210/jcem.81.8.8768836.
7
Renal clearance of the thyrotropin-releasing hormone-like peptide pyroglutamyl-glutamyl-prolineamide in humans.人促甲状腺激素释放激素样肽焦谷氨酰-谷氨酰-脯氨酰胺的肾清除率
J Clin Endocrinol Metab. 1997 Sep;82(9):3068-73. doi: 10.1210/jcem.82.9.4219.
8
Evidence for the presence of the putative TRH metabolite, deamido-TRH, in human urine.在人尿液中存在假定的促甲状腺激素释放激素（TRH）代谢物——脱酰胺基TRH的证据。
J Clin Endocrinol Metab. 1980 Aug;51(2):410-2. doi: 10.1210/jcem-51-2-410.
9
Radioimmunoassay for thyrotropin-releasing hormone precursor peptide, Lys-Arg-Gln-His-Pro-Gly-Arg-Arg.促甲状腺激素释放激素前体肽（赖氨酸-精氨酸-谷氨酰胺-组氨酸-脯氨酸-甘氨酸-精氨酸-精氨酸）的放射免疫测定法
Exp Clin Endocrinol. 1989 Apr;93(1):53-60. doi: 10.1055/s-0029-1210836.
10
Radioimmunoassay of thyrotropin releasing hormone in plasma and urine.血浆和尿液中促甲状腺激素释放激素的放射免疫测定
Endocrinol Jpn. 1975 Aug;22(4):303-9. doi: 10.1507/endocrj1954.22.303.

引用本文的文献

1
Three TRH-like molecules are released from rat hypothalamus in vitro.三种促甲状腺激素释放激素样分子在体外从大鼠下丘脑释放出来。
Neurochem Res. 1999 Jul;24(7):815-23. doi: 10.1023/a:1020993527602.
2
Thyrotropin-releasing hormone in the systemic circulation of the neonatal rat is derived from the pancreas and other extraneural tissues.新生大鼠体循环中的促甲状腺激素释放激素源自胰腺和其他神经外组织。
J Clin Invest. 1981 Mar;67(3):800-8. doi: 10.1172/JCI110097.
3
Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina: selective effect of light deprivation.
大鼠下丘脑、胰腺和视网膜中促甲状腺激素释放激素样物质的个体发育模式：光剥夺的选择性作用。
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4345-8. doi: 10.1073/pnas.77.7.4345.
4
Ultrastructural localization of TRH-like immunoreactivity.促甲状腺激素释放激素样免疫反应性的超微结构定位
Exp Brain Res. 1980;38(1):1-10. doi: 10.1007/BF00237924.
5
Glycine-directed peptide amidation: presence in rat brain of two enzymes that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 (thyrotropin-releasing hormone).甘氨酸导向的肽酰胺化作用：大鼠脑中存在两种将对-谷氨酸-组氨酸-脯氨酸-甘氨酸-OH 转化为对-谷氨酸-组氨酸-脯氨酸-NH2（促甲状腺激素释放激素）的酶。
Proc Natl Acad Sci U S A. 1984 May;81(10):3228-32. doi: 10.1073/pnas.81.10.3228.