大鼠下丘脑、胰腺和视网膜中促甲状腺激素释放激素样物质的个体发育模式：光剥夺的选择性作用。
Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina: selective effect of light deprivation.
作者信息
Martino E, Seo H, Lernmark A, Refetoff S
出版信息
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4345-8. doi: 10.1073/pnas.77.7.4345.
Abstract
Recent observations have shown the presence of thyrotropin-releasing hormone-like material (TRH-LM) in rat pancreatic islets and in retina. Its immunological and biological properties are identical to those of synthetic thyrotropin-releasing hormone (thyroliberin). This communication deals with the ontogenesis of TRH-LM in rat pancreas and retina as compared to that of rat hypothalamus. Effects of sex and exposure to constant dark were also studied. Results show that asynchronous changes in the concentration of TRH-LM occur during the postnatal maturation of these tissues, presumably mediated by organ-specific control mechanisms--e.g., light affects only the accumulation of TRH-LM in the retina. TRH-LM may act as neurotransmitter in the regulation of pancreatic islet cell function and in the development of photo-reception in the retina. Increases in hypothalamic TRH-LM seem to parallel the development of the pituitary-thyroid secretory activity, but the function of extrahypothalamic TRH-LM remains speculative.
摘要
最近的观察结果显示，大鼠胰岛和视网膜中存在促甲状腺激素释放激素样物质（TRH-LM）。其免疫学和生物学特性与合成促甲状腺激素释放激素（促甲状腺素释放素）相同。本文探讨了大鼠胰腺和视网膜中TRH-LM的个体发生过程，并与大鼠下丘脑的情况进行了比较。同时还研究了性别和持续黑暗暴露的影响。结果表明，这些组织在出生后成熟过程中，TRH-LM浓度会发生异步变化，推测这是由器官特异性控制机制介导的——例如，光照仅影响视网膜中TRH-LM的积累。TRH-LM可能作为神经递质参与调节胰岛细胞功能以及视网膜光感受器的发育。下丘脑TRH-LM的增加似乎与垂体-甲状腺分泌活动的发育平行，但下丘脑外TRH-LM的功能仍有待推测。
相似文献
1
Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina: selective effect of light deprivation.大鼠下丘脑、胰腺和视网膜中促甲状腺激素释放激素样物质的个体发育模式：光剥夺的选择性作用。
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4345-8. doi: 10.1073/pnas.77.7.4345.
2
High concentration of thyrotropin-releasing hormone in pancreatic islets.胰岛中促甲状腺激素释放激素的高浓度。
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4265-7. doi: 10.1073/pnas.75.9.4265.
3
Thyrotropin-releasing hormone in the systemic circulation of the neonatal rat is derived from the pancreas and other extraneural tissues.新生大鼠体循环中的促甲状腺激素释放激素源自胰腺和其他神经外组织。
J Clin Invest. 1981 Mar;67(3):800-8. doi: 10.1172/JCI110097.
4
Pattern of thyrotropin-releasing hormone secretion from the adult and neonatal rat pancreas: comparison with insulin secretion.成年和新生大鼠胰腺促甲状腺激素释放激素的分泌模式：与胰岛素分泌的比较。
Endocrinology. 1992 Mar;130(3):1371-9. doi: 10.1210/endo.130.3.1537298.
5
Effects of dexamethasone on pancreatic growth and thyroliberin (TRH) content in neonatal rat pancreas.
Physiol Res. 1995;44(3):165-72.
6
Food deprivation decreases the blood TRH concentration in the rat.
Exp Clin Endocrinol. 1988 Mar;91(1):97-104. doi: 10.1055/s-0029-1210728.
7
Effects of continuous light and dark exposure on hypothalamic thyrotropin-releasing hormone in rats.持续光照和黑暗暴露对大鼠下丘脑促甲状腺激素释放激素的影响。
J Endocrinol Invest. 1985 Feb;8(1):31-3. doi: 10.1007/BF03350633.
8
Ontogeny of receptors for thyrotropin-releasing hormone in the rat brain.
Brain Res. 1986 Jan;389(1-2):85-8. doi: 10.1016/0165-3806(86)90175-6.
9
Brain thyrotropin-releasing hormone matures independently of the hypothalamus in the rat.在大鼠体内，脑促甲状腺激素释放激素独立于下丘脑成熟。
Horm Metab Res. 1985 Apr;17(4):181-3. doi: 10.1055/s-2007-1013486.
10
Biosynthesis and release of thyrotropin-releasing hormone immunoreactivity in rat pancreatic islets in organ culture. Effects of age, glucose, and streptozotocin.器官培养大鼠胰岛中促甲状腺激素释放激素免疫反应性的生物合成与释放。年龄、葡萄糖和链脲佐菌素的影响。
J Clin Invest. 1983 Dec;72(6):1867-73. doi: 10.1172/JCI111149.
引用本文的文献
1
Association between thyroid dysfunction and diabetic retinopathy: a two-sample bidirectional Mendelian randomization study.甲状腺功能障碍与糖尿病视网膜病变之间的关联：一项两样本双向孟德尔随机化研究。
Diabetol Metab Syndr. 2024 Dec 18;16(1):297. doi: 10.1186/s13098-024-01552-0.
2
Chrono-Endocrinology in Clinical Practice: A Journey from Pathophysiological to Therapeutic Aspects.临床实践中的时间内分泌学：从病理生理学到治疗层面的历程
Life (Basel). 2024 Apr 24;14(5):546. doi: 10.3390/life14050546.
3
Assessment of the association between genetic factors regulating thyroid function and microvascular complications in diabetes: A two-sample Mendelian randomization study in the European population.评估调节甲状腺功能的遗传因素与糖尿病微血管并发症之间的关联：欧洲人群的两样本孟德尔随机研究。
Front Endocrinol (Lausanne). 2023 Feb 28;14:1126339. doi: 10.3389/fendo.2023.1126339. eCollection 2023.
4
Chronothyroidology: Chronobiological Aspects in Thyroid Function and Diseases.时间甲状腺学：甲状腺功能与疾病中的生物钟学方面
Life (Basel). 2021 May 10;11(5):426. doi: 10.3390/life11050426.
5
High levels of thyrotropin-releasing hormone receptors activate programmed cell death in human pancreatic precursors.高水平的促甲状腺激素释放激素受体激活人类胰腺前体细胞的程序性细胞死亡。
Pancreas. 2009 Mar;38(2):197-202. doi: 10.1097/MPA.0b013e31818d14a8.
6
Comparison of the effects of intravenous and oral montelukast on airway function: a double blind, placebo controlled, three period, crossover study in asthmatic patients.静脉注射与口服孟鲁司特对气道功能影响的比较：一项针对哮喘患者的双盲、安慰剂对照、三阶段交叉研究。
Thorax. 2000 Apr;55(4):260-5. doi: 10.1136/thorax.55.4.260.
7
Light, blindness and endocrine secretions.光、失明与内分泌分泌物。
J Endocrinol Invest. 1999 Dec;22(11):874-85. doi: 10.1007/BF03343663.
8
Lipoxin A4: a novel anti-inflammatory molecule?脂氧素A4：一种新型抗炎分子？
Thorax. 1995 Feb;50(2):111-2. doi: 10.1136/thx.50.2.111.
9
Thyrotropin-releasing hormone in the pancreas and brain of the rat is regulated by central noradrenergic and dopaminergic pathways.大鼠胰腺和大脑中的促甲状腺激素释放激素受中枢去甲肾上腺素能和多巴胺能通路调控。
J Clin Invest. 1982 Jun;69(6):1310-20. doi: 10.1172/jci110571.
10
Thyrotropin-releasing hormone-like material in human retina.人类视网膜中的促甲状腺激素释放激素样物质。
J Endocrinol Invest. 1980 Jul-Sep;3(3):267-71. doi: 10.1007/BF03348274.
本文引用的文献
1
Thyrotropin-releasing hormone-like bioactivity in placenta: evidence for the existence of substances other than Pyroglu-His-Pro-NH2 (TRH) capable of stimulating pituitary thyrotropin release.
Endocrinology. 1980 Feb;106(2):541-6. doi: 10.1210/endo-106-2-541.
2
Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamide.合成焦谷氨酰-组氨酰-脯氨酰胺对人催乳素和促甲状腺激素释放的影响
Biochem Biophys Res Commun. 1971 Nov;45(4):1033-41. doi: 10.1016/0006-291x(71)90441-4.
3
The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide.促甲状腺激素释放激素与焦谷氨酰-组氨酰-脯氨酸酰胺的化学及激素特性一致性。
Biochem Biophys Res Commun. 1969 Nov 6;37(4):705-10. doi: 10.1016/0006-291x(69)90868-7.
4
[Synthetic polypeptide derivatives with thyrotropin releasing factor hypophysiotropic activity].具有促甲状腺素释放因子促垂体活性的合成多肽衍生物
C R Acad Hebd Seances Acad Sci D. 1969 Apr 21;268(16):2116-8.
5
Inhibition of growth hormone secretion in the rat by synthetic somatostatin.合成生长抑素对大鼠生长激素分泌的抑制作用。
Endocrinology. 1974 Jan;94(1):184-7. doi: 10.1210/endo-94-1-184.
6
Thyrotropin releasing hormone: enhancement of dopa activity by a hypothalamic hormone.促甲状腺激素释放激素：一种下丘脑激素对多巴活性的增强作用。
Science. 1972 Oct 27;178(4059):417-8. doi: 10.1126/science.178.4059.417.
7
Serum thyrotropin responses to synthetic thyrotropin-releasing hormone in normal children and hypopituitary patients. A new test to distinguish primary releasing hormone deficiency from primary pituitary hormone deficiency.正常儿童和垂体功能减退患者血清促甲状腺激素对合成促甲状腺激素释放激素的反应。一种区分原发性释放激素缺乏和原发性垂体激素缺乏的新测试。
J Clin Invest. 1972 Feb;51(2):431-7. doi: 10.1172/JCI106829.
8
TRH: a possible mediator of thermoregulation.促甲状腺激素释放激素：体温调节的一种可能介质。
Nature. 1974 Nov 22;252(5481):310-1. doi: 10.1038/252310a0.
9
Thyrotropin-releasing hormone (TRH): distribution in hypothalamic and extrahypothalamic brain tissues of mammalian and submammalian chordates.促甲状腺激素释放激素（TRH）：在哺乳动物和亚哺乳动物脊索动物的下丘脑及下丘脑外脑组织中的分布。
Endocrinology. 1974 Sep;95(3):854-62. doi: 10.1210/endo-95-3-854.
10
Distribution and concentration of TRH in the rat brain.促甲状腺激素释放激素在大鼠脑中的分布与浓度
Endocrinology. 1974 Aug;95(2):540-6. doi: 10.1210/endo-95-2-540.
Zotero 插件