Nesterov Iu I, Gol'dberg G A
Ter Arkh. 1998;70(9):64-7.
To assess effectiveness of blood hypertension treatment with inhibitors of angiotensin converting enzyme and calcium channels blocker.
83 outpatients with mild and moderate blood hypertension received monotherapy with prestarium, anap and lomir for 12 months. The trends in parameters of blood pressure, total peripheral vascular resistance, thickness of the interventricular septum and left ventricular posterior wall were estimated.
Long-term effective monotherapy with prestarium, anap and lomir was possible in 47, 62 and 45% of the patients, respectively. Diastolic pressure lowered by 25, 24 and 25%, total peripheral vascular resistance reduced by 20, 19 and 22%, respectively. The three drugs produced similar positive effects on left ventricular thickness, had no negative effects on bioelectric activity of the heart, clinical and biochemical blood counts.
Prestarium, anap and lomir are effective against hypertension and diminish left ventricular hypertrophy in hypertensive patients.
评估血管紧张素转换酶抑制剂和钙通道阻滞剂治疗高血压的效果。
83例轻、中度高血压门诊患者接受了为期12个月的普瑞斯塔林、阿纳普和洛米尔单药治疗。评估了血压、总外周血管阻力、室间隔厚度和左心室后壁厚度参数的变化趋势。
长期使用普瑞斯塔林、阿纳普和洛米尔进行有效单药治疗的患者分别占47%、62%和45%。舒张压分别降低了25%、24%和25%，总外周血管阻力分别降低了20%、19%和22%。这三种药物对左心室厚度产生了相似的积极影响，对心脏生物电活动、临床和生化血细胞计数均无负面影响。
普瑞斯塔林、阿纳普和洛米尔对高血压有效，并可减轻高血压患者的左心室肥厚。
