Rabinowitz J E, Samulski J
Human Gene Therapy Center, University of North Carolina at Chapel Hill 27599-7352, USA.
Curr Opin Biotechnol. 1998 Oct;9(5):470-5. doi: 10.1016/s0958-1669(98)80031-1.
In contrast to other gene delivery systems, adeno-associated virus vectors show long term gene expression without immune response or toxicity. New production methods have increased vector titers and eliminated adenovirus contamination, thereby facilitating effective in vivo use. These advancements will expedite additional animal model studies providing validation for use of this vector in human clinical trials.
与其他基因递送系统相比，腺相关病毒载体可实现长期基因表达，且无免疫反应或毒性。新的生产方法提高了载体滴度并消除了腺病毒污染，从而便于在体内有效使用。这些进展将加快更多动物模型研究，为该载体在人类临床试验中的应用提供验证。
