Holmes M D, Dodrill C B, Wilkus R J, Ojemann L M, Ojemann G A
Department of Neurology, University of Washington, Seattle, USA.
Epilepsia. 1998 Nov;39(11):1189-93. doi: 10.1111/j.1528-1157.1998.tb01310.x.
This study was undertaken to determine what changes, if any, occur in the electroencephalogram (EEG) and in neuropsychological test findings of adults with medically intractable complex partial epilepsy over a 10-year period.
We studied 35 adults, with a mean age of 32 years (range, 16-59 years) at time of initial testing. We compared the distribution of epileptiform patterns documented on the initial pair of waking and sleeping EEGs to those observed on another pair obtained 10 years later. During this same 10-year period, we also examined changes in the Wechsler Adult Intelligence Scale (WAIS) and on the tests from the Neuropsychological Battery for Epilepsy.
The EEGs of 28 (80%) of patients at the tenth year were identical to those seen initially. Five (14%) of patients demonstrated EEGs after 10 years with either no discharges or only unilateral discharges, where bilateral discharges were seen a decade earlier. Only two (6%) of patients had EEGs at the tenth year that showed bilateral discharges where only unilateral discharges were seen originally. We found no general change in intelligence or neuropsychological functioning after 10 years, although a few subtle losses were noted on several neuropsychological measures.
For most adults with medically intractable complex partial epilepsy, the EEG and neuropsychological test scores remain reasonably stable over a decade.
本研究旨在确定患有药物难治性复杂部分性癫痫的成年人在10年期间脑电图（EEG）及神经心理学测试结果是否发生了变化（若有变化）。
我们研究了35名成年人，初次测试时平均年龄为32岁（范围16 - 59岁）。我们将初次清醒和睡眠脑电图记录的癫痫样放电模式分布与10年后获取的另一组脑电图上观察到的模式进行了比较。在这相同的10年期间，我们还检查了韦氏成人智力量表（WAIS）以及癫痫神经心理学成套测验的测试结果变化。
在第10年时，28名（80%）患者的脑电图与最初观察到的相同。5名（14%）患者在10年后脑电图显示无放电或仅有单侧放电，而10年前可见双侧放电。仅2名（6%）患者在第10年时脑电图显示双侧放电，而最初仅见单侧放电。我们发现10年后智力或神经心理功能无总体变化，尽管在几项神经心理学测量中发现了一些细微的减退。
对于大多数患有药物难治性复杂部分性癫痫的成年人，脑电图和神经心理学测试分数在十年间保持相对稳定。
