Wilkus R J, Dodrill C B
Epilepsia. 1976 Mar;17(1):89-100. doi: 10.1111/j.1528-1157.1976.tb03387.x.
In 57 male and 33 female uncontrolled adult epileptics treated solely by diphenylhydantoin, scores on a broad battery of neuropsychological tests were compared with the separate and simultaneous consideration of the topographic distribution and average rate of occurrence of their EEG epileptiform discharges. These studies were given within a median of 1.24 days of each other. In the battery of tests, it was statistically significant that the group with generalized discharges did the poorest, patients with focal epileptiform activity were intermediate, and those without discharges did the best. When the rates of occurrence of discharges were compared to the neuropsychological test scores, results were less often significantly correlated with the EEG findings. In general, however, individuals with discharges occurring at the rate of more than 1/min did worse than those with fewer discharges. When the topographic distribution and average rate variables were considered in combination, their impacts on psychological performance were cumulative. The results suggest that EEG epileptiform discharges serve as an index of brain function having a bearing upon neuropsychological performance of epileptics.
在57名男性和33名女性成年癫痫患者中，这些患者仅接受苯妥英治疗且病情未得到控制。将一系列广泛的神经心理学测试得分，与对脑电图癫痫样放电的地形分布和平均出现率分别及同时进行的考量进行了比较。这些研究在彼此间隔的中位数为1.24天内进行。在这一系列测试中，具有全身性放电的组表现最差，有局灶性癫痫样活动的患者居中，而无放电的患者表现最佳，这在统计学上具有显著意义。当将放电出现率与神经心理学测试得分进行比较时，结果与脑电图结果的显著相关性较低。然而，总体而言，放电频率超过每分钟1次的个体比放电频率较低的个体表现更差。当综合考虑地形分布和平均频率变量时，它们对心理表现的影响是累积性的。结果表明，脑电图癫痫样放电可作为一种脑功能指标，对癫痫患者的神经心理学表现产生影响。
