透明质酸在药物靶向与药物递送方面的见解。

An insight on hyaluronic acid in drug targeting and drug delivery.

作者信息

Yadav Awesh K, Mishra P, Agrawal Govind P

机构信息

Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University, Sagar, India.

出版信息

J Drug Target. 2008 Feb;16(2):91-107. doi: 10.1080/10611860802095494.

DOI:10.1080/10611860802095494

PMID:18274931

Abstract

Hyaluronic acid (HA) has recently been studied for its use in drug delivery applications. Medically, HA is used as a surgical aid in ophthalmology. It also possesses therapeutic potential in the treatment of arthritis and wound healing. HA-binding receptors, CD44 and receptor for hyaluronan-mediated motility have attracted much enthusiasm, mainly because they are believed to be involved in cancer metastasis. This review unravels the role of HA in drug delivery and targeting. Designing of various novel drug delivery systems using HA as a biopolymer will also be reviewed in the present article.

摘要

透明质酸（HA）最近因其在药物递送应用中的用途而受到研究。在医学上，HA被用作眼科手术辅助剂。它在关节炎治疗和伤口愈合方面也具有治疗潜力。HA结合受体，即CD44和透明质酸介导的运动受体，引起了广泛关注，主要是因为它们被认为与癌症转移有关。本综述揭示了HA在药物递送和靶向中的作用。本文还将综述以HA作为生物聚合物设计各种新型药物递送系统的情况。