Nakamura A, Yokoyama T, Kodera S, Zhang D, Hirose S, Shirai T, Kanai A
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
Jpn J Ophthalmol. 1998 Sep-Oct;42(5):345-51. doi: 10.1016/s0021-5155(98)00023-9.
We investigated the ocular fundus of (NZWXBXSB) F1 mice, which are considered to be a good model for systemic lupus erythematosus (SLE) with antiphospholipid syndrome. The abnormal fundus findings were documented by fundus photography, and the chorioretinal lesions were studied histopathologically. The incidence of ocular fundus abnormalities and systemic signs in these F1 mice was significantly higher in males than in females, as with the systemic symptoms. This indicated an influence of the Yaa (Y chromosome-linked autoimmune acceleration) gene. Lesions in the fundus appeared as white spots, which increased in number during the course of the disease and developed into retinal detachment in some animals. This developmental course resembled the course of patients with multifocal posterior pigment epitheliopathy. Dilatation of the veins and narrowing of arteries were marked. Histopathological findings included: (1) destruction of the photoreceptor cell layer, (2) degeneration and loss of the retinal pigment epithelium, (3) thickening of the wall of the choroidal arterioles, and (4) narrowing and occlusion of the choriocapillaris associated with hyaline degeneration and thrombus formation. The study of the SLE mouse model should contribute to the understanding of the abnormalities in the fundus associated with collagen diseases.
我们研究了（NZWXBXSB）F1小鼠的眼底，该小鼠被认为是患有抗磷脂综合征的系统性红斑狼疮（SLE）的良好模型。通过眼底摄影记录异常眼底表现，并对脉络膜视网膜病变进行组织病理学研究。与全身症状一样，这些F1小鼠中男性的眼底异常和全身体征的发生率显著高于女性。这表明了Yaa（Y染色体连锁自身免疫加速）基因的影响。眼底病变表现为白色斑点，在疾病过程中数量增加，在一些动物中发展为视网膜脱离。这种发展过程类似于多灶性后色素上皮病变患者的病程。静脉扩张和动脉狭窄明显。组织病理学发现包括：（1）光感受器细胞层破坏，（2）视网膜色素上皮变性和丧失，（3）脉络膜小动脉壁增厚，（4）脉络膜毛细血管狭窄和闭塞，伴有玻璃样变性和血栓形成。对SLE小鼠模型的研究应有助于理解与胶原病相关的眼底异常。
