Mohyi D L, Kerdelhué B, Lenoir V, Kolm P, Jones H W, Jones G S
Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
J Assist Reprod Genet. 1998 Oct;15(9):547-51. doi: 10.1023/a:1022534204239.
This study was designed to examine changes in peripheral plasma substance-P and -K levels, their association with follicle-stimulating hormone and luteinizing hormone release in normal reproductive cycles in humans, and their correlation with plasma estradiol and progesterone.
Fourteen healthy, normally menstruating women underwent daily blood sampling (cycle day 4, 4-14 days) for measurement of estradiol, progesterone, luteinizing hormone, and follicle-stimulating hormone, substances-P and -K, and daily transvaginal ultrasounds assessing follicular growth and documentation of ovulation.
Estradiol peaked on day 13, luteinizing hormone and follicle-stimulating hormone peaked on day 14, and progesterone began an exponential increase on about day 13.
In contrast to other experimental designs using in vitro or in vivo rat or monkey tissue, peripheral levels of substances-P (P = 0.8391) and -K (P = 0.3205) reflected no modulation related to midcycle gonadotropin release in cycling woman.
本研究旨在检测正常人类生殖周期中外周血血浆P物质和钾离子水平的变化，它们与促卵泡激素和促黄体生成素释放的关系，以及它们与血浆雌二醇和孕酮的相关性。
14名健康、月经周期正常的女性每天进行采血（月经周期第4天、第4 - 14天），以检测雌二醇、孕酮、促黄体生成素、促卵泡激素、P物质和钾离子水平，并每天进行经阴道超声检查，评估卵泡生长情况并记录排卵情况。
雌二醇在第13天达到峰值，促黄体生成素和促卵泡激素在第14天达到峰值，孕酮在大约第13天开始呈指数级增加。
与其他使用体外或体内大鼠或猴组织的实验设计不同，在月经周期中的女性外周血中，P物质（P = 0.8391）和钾离子（P = 0.3205）水平未显示出与中期促性腺激素释放相关的调节作用。
