钙促排灵诱导小鼠胎儿死亡和畸形。

Ca-DTPA-induced fetal death and malformation in mice.

作者信息

Fisher D R, Calder S E, Mays C W, Taylor G N

出版信息

Teratology. 1976 Oct;14(2):123-7. doi: 10.1002/tera.1420140202.

DOI:10.1002/tera.1420140202

Abstract

Increased fetal mortality and congenital malformation were induced in mice by Ca-DTPA, a chelate widely used for the removal of internally deposited plutonium in human beings. Mated C57BL/Do female mice were given five daily injections of 720-2,880 mumol/kg Ca-DTPA during early, mid, or late gestation. Damage probably occurred as a result of the depletion by Ca-DTPA of zinc and manganese, trace elements essential to growth and development. By extension, it seems likely that Ca-DTPA could damage human fetuses. A much safer chelate, Zn-DTPA, is recommended for the treatment of accidental plutonium contamination.

摘要

广泛用于清除人体内部沉积钚的螯合剂Ca-DTPA可导致小鼠胎儿死亡率增加和先天性畸形。在妊娠早期、中期或晚期，对交配后的C57BL/Do雌性小鼠每日注射5次，剂量为720 - 2880 μmol/kg的Ca-DTPA。损害可能是由于Ca-DTPA耗尽了生长和发育所必需的微量元素锌和锰所致。由此推断，Ca-DTPA似乎有可能损害人类胎儿。推荐使用一种安全得多的螯合剂Zn-DTPA来治疗意外钚污染。