Hendler A, Hershkop M
Department of Nuclear Medicine, University of Toronto Faculty of Medicine, Ontario, Canada.
Postgrad Med. 1998 Nov;104(5):54-6, 59-61, 65-6 passim. doi: 10.3810/pgm.1998.11.401.
Despite advances in nuclear medicine, bone scintigraphy remains an important imaging technique. It is sensitive in detecting stress fractures and bone metastases and can assess suspected injury that is difficult to see on plain films (e.g., rib fracture). Scintigraphy is useful in evaluating new symptoms, response to therapy, and prognosis in patients with known malignant tumor. In patients with low back pain, the technique can determine the age of fractures to help identify osteoporosis and can uncover other causes of the pain (e.g., spondylolysis, arthritis). When Paget's disease is suggested by unexplained bone pain or an elevated serum alkaline phosphatase level, bone scintigraphy is a useful screening test. Combined with other appropriate nuclear medicine studies, it helps in early identification and localization of osteomyelitis. Scintigraphic scans can provide a general indicator of malignant versus benign disease (according to the amount of lesion activity seen) and may produce characteristic findings in certain primary tumors (e.g., osteoid osteoma) that are difficult to evaluate with other methods.
尽管核医学取得了进展，但骨闪烁显像仍然是一项重要的成像技术。它在检测应力性骨折和骨转移方面很敏感，并且可以评估在平片上难以发现的可疑损伤（例如肋骨骨折）。闪烁显像在评估已知恶性肿瘤患者的新症状、对治疗的反应和预后方面很有用。对于腰痛患者，该技术可以确定骨折的年龄以帮助识别骨质疏松症，并可以发现疼痛的其他原因（例如椎弓崩裂、关节炎）。当不明原因的骨痛或血清碱性磷酸酶水平升高提示佩吉特病时，骨闪烁显像是一项有用的筛查试验。与其他适当的核医学研究相结合，有助于早期识别和定位骨髓炎。闪烁扫描可以根据所见病变活动量提供恶性与良性疾病的一般指标，并且可能在某些用其他方法难以评估的原发性肿瘤（例如骨样骨瘤）中产生特征性表现。
