Kuramitsu Y, Hamada J, Tsuruoka T, Morikawa K, Naito S, Kobayashi H, Hosokawa M
Laboratories of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
Anticancer Drugs. 1998 Sep;9(8):739-41. doi: 10.1097/00001813-199809000-00010.
Explants of highly metastatic human renal cell carcinoma SN12Cpm6 cells in athymic mice were treated with sodium D-glucaro-delta-lactam (sodium 5-amino-5-deoxy-D-glucosaccharic acid-delta-lactam; ND-2001). ND-2001 (50 micrograms/ml) caused 78% inhibition of lung metastasis of SN12Cpm6 cells (two of five animals remaining metastasis free). The in vitro tumor cell invasion assay showed that ND-2001 (100 micrograms/ml) suppressed the invasive activity of SN12Cpm6 cells to Matrigel matrix at an inhibition rate of 72%. These results suggest that ND-2001 may be a new anti-metastatic drug against human cancer cells.
将高度转移性人肾细胞癌SN12Cpm6细胞接种于无胸腺小鼠体内形成的外植体，用D - 葡糖醛酸 - δ - 内酯钠（5 - 氨基 - 5 - 脱氧 - D - 葡糖二酸 - δ - 内酯钠；ND - 2001）进行处理。ND - 2001（50微克/毫升）对SN12Cpm6细胞的肺转移抑制率达78%（五只动物中有两只无转移）。体外肿瘤细胞侵袭试验表明，ND - 2001（100微克/毫升）对SN12Cpm6细胞向基质胶基质的侵袭活性的抑制率为72%。这些结果表明，ND - 2001可能是一种新型抗人癌细胞转移的药物。
