Nakatsugawa S, Okuda T, Muramoto H, Koyama K, Ishigaki T, Tsuruoka T, Hosokawa M, Kobayashi H
Department of Radiology, Nagoya University, Japan.
Anticancer Drugs. 1999 Feb;10(2):229-33. doi: 10.1097/00001813-199902000-00012.
The NC 65 tumor cell line derived from human renal cell carcinoma was selected from among nine human cell lines by determining the inhibition of invasion by ND2001 (sodium D-glucaro-delta-lactam) in vitro. The efficacy of this agent against these tumor cells was investigated in an experimental metastatic model of human tumors in vivo. Although ND2001 did not inhibit growth of NC 65 cells intradermally transplanted into male KSN mice (nu/nu), this agent inhibited multiple spontaneous metastasis.
通过在体外测定ND2001（D-葡萄糖酸-δ-内酯钠）对侵袭的抑制作用，从九种人类细胞系中筛选出了源自人肾细胞癌的NC 65肿瘤细胞系。在人肿瘤的实验性体内转移模型中研究了该药物对这些肿瘤细胞的疗效。尽管ND2001对皮内移植到雄性KSN小鼠（裸鼠）体内的NC 65细胞的生长没有抑制作用，但该药物抑制了多种自发转移。
