O'Mahony D, Foote C
Department of Medicine for the Elderly, Wycombe General Hospital, High Wycombe, Buckinghamshire, United Kingdom.
J Gerontol A Biol Sci Med Sci. 1998 Nov;53(6):M435-40. doi: 10.1093/gerona/53a.6.m435.
Unexplained syncope, dizziness, and falls may present a difficult diagnostic challenge to primary care and emergency room physicians. The aim of this study was to evaluate a diagnostic algorithm in the assessment of a cohort of community-dwelling elderly people with symptoms of unexplained syncope, falls, or dizziness.
Fifty-four consecutive elderly patients (mean age + SD = 76.4 + 8.0 years, range 61-91) were assessed over a 12-month period. Presenting symptoms were syncope in 33 patients (61.1%), unexplained falls without loss of consciousness in 10 patients (18.5%), and dizziness without loss of consciousness in 11 (20.4%), and true vertigo in 2 patients (3.7%). Patients were assessed systematically using the algorithm, followed up until a diagnosis was made, and appropriate preventive therapy or advice given.
Diagnoses were obtained in 41 patients (75.9%). Of the 33 patients with syncope, the cause was identified in 23 (69.7%) as follows: vasovagal in 12, arrhythmia in 5, hypotensive drugs in 3, orthostatic hypotension in 2, and major anxiety with hyperventilation in 1. The cause of syncope remained uncertain in 10 patients. Among the 10 patients with nonsyncopal falls, the cause was identified in 9 as follows: drop attacks with associated knee osteoarthritis or quadriceps muscle weakness in 3, orthostatic hypotension in 2, and single cases of cerebellar ataxia, Parkinson's disease, otologic vertigo, and vertebrobasilar insufficiency. Of 11 patients with dizziness, 4 had vasovagal syncope, 2 had orthostatic hypotension, 2 had otologic vertigo, one had carotid sinus syndrome, and the cause remained obscure in 2. Nineteen of the 41 patients (46.3%) had at least one other abnormality that was possibly contributory to their symptoms. Five of the 13 patients without a clearcut diagnosis had abnormalities of possible significance, including first-degree heart block with fascicular block in 2 patients and individual patients with severe hypertension, aortic valve disease, and vasodepressor carotid sinus hypersensitivity.
A targeted, problem-oriented algorithm indicates the diagnosis in three quarters of elderly patients with unexplained syncope, falls, and dizziness.
不明原因的晕厥、头晕和跌倒可能给初级保健医生和急诊室医生带来诊断难题。本研究的目的是评估一种诊断算法,用于评估一组有不明原因晕厥、跌倒或头晕症状的社区老年人群。
在12个月期间对54例连续的老年患者(平均年龄±标准差 = 76.4±8.0岁,范围61 - 91岁)进行评估。出现的症状为:33例患者(61.1%)为晕厥,10例患者(18.5%)为无意识丧失的不明原因跌倒,11例患者(20.4%)为无意识丧失的头晕,2例患者(3.7%)为真性眩晕。使用该算法对患者进行系统评估,随访直至做出诊断,并给予适当的预防性治疗或建议。
41例患者(75.9%)得到诊断。在33例晕厥患者中,23例(69.7%)病因明确,如下:血管迷走性晕厥12例,心律失常5例,降压药物所致3例,体位性低血压2例,伴有过度通气的重度焦虑1例。10例患者晕厥病因仍不确定。在10例非晕厥性跌倒患者中,9例病因明确,如下:伴有膝关节骨关节炎或股四头肌无力的跌倒发作3例,体位性低血压2例,以及小脑共济失调、帕金森病、耳性眩晕和椎基底动脉供血不足各1例。在11例头晕患者中,4例为血管迷走性晕厥,2例为体位性低血压,2例为耳性眩晕,1例为颈动脉窦综合征,2例病因不明。41例患者中有19例(46.3%)至少有一项其他异常,可能与他们的症状有关。13例未明确诊断的患者中有5例有可能具有重要意义的异常,包括2例一度房室传导阻滞伴分支阻滞,以及分别患有重度高血压、主动脉瓣疾病和血管减压性颈动脉窦过敏症各1例。
一种有针对性的、以问题为导向的算法可在四分之三有不明原因晕厥、跌倒和头晕的老年患者中明确诊断。