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A mammalian sperm cytosolic phospholipase C activity generates inositol trisphosphate and causes Ca2+ release in sea urchin egg homogenates.

作者信息

Jones K T, Cruttwell C, Parrington J, Swann K

机构信息

Department of Anatomy and Developmental Biology, University College, London, UK.

出版信息

FEBS Lett. 1998 Oct 23;437(3):297-300. doi: 10.1016/s0014-5793(98)01254-x.

DOI:10.1016/s0014-5793(98)01254-x
PMID:9824311
Abstract

Injection of sperm extracts triggers Ca2+ oscillations in mammalian eggs similar to those seen at fertilisation. Here, we show that addition of sperm extracts to sea urchin egg homogenates causes Ca2+ release and inositol 1,4,5-trisphosphate (InsP3) production. Furthermore depleting homogenates of phosphatidylinositol lipids using a phosphatidylinositol-specific phospholipase C blocked the sperm extract from causing InsP3 production and a Ca2+ rise. A response could be recovered by the addition of phosphatidylinositol 4,5-bisphosphate to either sperm extracts or egg homogenates. These data indicate that sperm extracts contain an InsP3-generating phospholipase C which may play a role in Ca2+ release at fertilisation.

摘要

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