Franzè A, Ferrante M I, Fusco F, Santoro A, Sanzari E, Martini G, Ursini M V
Istituto Internazionale di Genetica e Biofisica, CNR, Naples, Italy.
FEBS Lett. 1998 Oct 23;437(3):313-8. doi: 10.1016/s0014-5793(98)01259-9.
The gene encoding glucose 6-phosphate dehydrogenase (G6PD), which plays a pivotal role in cell defense against oxidative stress, is ubiquitously expressed at widely different levels in various tissues; moreover, G6PD expression is regulated by a number of stimuli. In this study we have analyzed the molecular anatomy of the G6PD core promoter. Our results indicate that the G6PD promoter is more complex than previously assumed; G6PD expression is under the control of several elements that are all required for correct promoter functioning and, furthermore, a still unidentified mammalian specific factor is needed.
编码葡萄糖6-磷酸脱氢酶（G6PD）的基因在细胞抵御氧化应激中起关键作用，该基因在各种组织中广泛表达，但其表达水平差异很大；此外，G6PD的表达受多种刺激因素调控。在本研究中，我们分析了G6PD核心启动子的分子结构。我们的结果表明，G6PD启动子比之前设想的更为复杂；G6PD的表达受多个元件控制，这些元件都是启动子正常运作所必需的，此外，还需要一个尚未明确的哺乳动物特异性因子。
