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2
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Expression and function of NKRP1A molecule on human monocytes and dendritic cells.NKRP1A分子在人单核细胞和树突状细胞上的表达及功能
Eur J Immunol. 1997 Nov;27(11):2965-70. doi: 10.1002/eji.1830271132.
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Preliminary study of how alcohol consumption during pregnancy affects immune components in breast milk and blood of postpartum women.孕期饮酒对产后女性母乳和血液中免疫成分影响的初步研究。
Alcohol Alcohol. 1997 Sep-Oct;32(5):581-9. doi: 10.1093/oxfordjournals.alcalc.a008299.
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Prostaglandin E2 and tumor necrosis factor alpha cooperate to activate human dendritic cells: synergistic activation of interleukin 12 production.前列腺素E2与肿瘤坏死因子α协同激活人树突状细胞：白细胞介素12产生的协同激活作用。
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Interleukin-10 inhibits tumor metastasis, downregulates MHC class I, and enhances NK lysis.白细胞介素-10可抑制肿瘤转移，下调I类主要组织相容性复合体，并增强自然杀伤细胞的细胞溶解作用。
Cell Immunol. 1997 Aug 25;180(1):55-61. doi: 10.1006/cimm.1997.1176.
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TGF-beta 2 and PGE2 in rabbit blastocoelic fluid can modulate GM-CSF production by human lymphocytes.兔胚泡腔液中的转化生长因子-β2和前列腺素E2可调节人淋巴细胞产生粒细胞-巨噬细胞集落刺激因子。
Am J Reprod Immunol. 1997 Aug;38(2):129-39. doi: 10.1111/j.1600-0897.1997.tb00287.x.
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Effects of colony-stimulating factors on cellular cytotoxicity.集落刺激因子对细胞毒性的影响。
Cancer Immunol Immunother. 1997 Mar;44(1):35-40. doi: 10.1007/s002620050352.
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IL-10 production in mouse hepatocytes augmented by TGF-beta.转化生长因子-β增强小鼠肝细胞中白细胞介素-10的产生。
Cytokine. 1996 Nov;8(11):837-43. doi: 10.1006/cyto.1996.0112.
8
Up-regulation of tubular epithelial interleukin-12 in autoimmune MRL-Fas(lpr) mice with renal injury.自身免疫性MRL-Fas（lpr）肾损伤小鼠肾小管上皮白细胞介素-12的上调。
Kidney Int. 1997 Jan;51(1):79-86. doi: 10.1038/ki.1997.10.
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Induction of interleukin-1 and interleukin-8 mRNAs and proteins by TGF beta 1 in rat lung alveolar epithelial cells.转化生长因子β1在大鼠肺泡上皮细胞中诱导白细胞介素-1和白细胞介素-8信使核糖核酸及蛋白质的产生
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The cytokine microenvironment of human colon carcinoma. Lymphocyte expression of tumor necrosis factor-alpha and interleukin-4 predicts improved survival.人类结肠癌的细胞因子微环境。肿瘤坏死因子-α和白细胞介素-4的淋巴细胞表达预示着生存期延长。
Cancer. 1996 Sep 15;78(6):1168-78. doi: 10.1002/(SICI)1097-0142(19960915)78:6<1168::AID-CNCR2>3.0.CO;2-6.

通过口服转化生长因子-β增强小鼠自然杀伤细胞活性。

Augmentation of natural killer cell activity in mice by oral administration of transforming growth factor-beta.

作者信息

Ishizaka S, Kimoto M, Kanda S, Saito S

机构信息

Department of Parasitology, Nara Medical University, Kashihara, Japan.

出版信息

Immunology. 1998 Nov;95(3):460-5. doi: 10.1046/j.1365-2567.1998.00652.x.

DOI:10.1046/j.1365-2567.1998.00652.x
PMID:9824511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1364414/
Abstract

The latent form of transforming growth factor-beta (TGF-beta) in human milk and platelets was converted to the active form when conscious, pylorus-ligated mice were given human milk and platelets by intragastric intubation. Oral administration of TGF-beta exerted enhancing effects on the natural killer (NK)-cell activities in spleen and liver. Augmentation of NK-cell activities in spleen was observed for 7 days after oral administration of TGF-beta. TGF-beta at concentrations of 5 and 20 ng produced the greatest augmentation of NK-cell activities in spleen. However, NK-cell activities in spleen were unaffected when TGF-beta was given intravenously. Interleukin (IL)-12 production in spleen was enhanced by oral administration of TGF-beta, but not by intravenous administration of TGF-beta. These findings suggest that large amounts of TGF-beta in human milk are involved in early antiviral protection through the augmentation of NK-cell activities.

摘要

当对清醒的幽门结扎小鼠进行灌胃给予人乳和血小板时，人乳和血小板中转化生长因子β（TGF-β）的潜伏形式会转化为活性形式。口服TGF-β对脾脏和肝脏中的自然杀伤（NK）细胞活性具有增强作用。口服TGF-β后7天可观察到脾脏中NK细胞活性增强。浓度为5和20 ng的TGF-β可使脾脏中NK细胞活性增强最为显著。然而，静脉注射TGF-β时，脾脏中的NK细胞活性未受影响。口服TGF-β可增强脾脏中白细胞介素（IL）-12的产生，但静脉注射TGF-β则无此作用。这些发现表明，人乳中大量的TGF-β通过增强NK细胞活性参与早期抗病毒保护。