Schneider J S, Schroeder J A, Rothblat D S
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA.
Brain Res. 1998 Nov 30;813(1):82-7. doi: 10.1016/s0006-8993(98)01007-5.
Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to cats results in a parkinsonian syndrome characterized by rigidity, akinesia, bradykinesia, decreased response to external sensory stimuli and depletion of nigrostriatal dopamine. Cats spontaneously recover gross sensorimotor functions despite little recovery of the dopaminergic innervation of the striatum. In contrast, GM1 ganglioside administration accelerates gross behavioral recovery and causes an increased dopaminergic innervation of the striatum. This study examined whether these two recovery conditions are characterized by different degrees of functional recovery. Cats were trained to perform a sensorimotor reaching task prior to MPTP exposure and were then re-tested on the task 6 weeks later after spontaneously recovering gross motor functioning or after 6 weeks of GM1 treatment. Gross motor recovery was similar in both groups. However, the spontaneously recovered cats had significant difficulty in performing the task while GM1-treated cats performed normally. GM1-treated cats also had significant increases in striatal [3H]mazindol binding compared to spontaneously recovered cats. These results suggest that while gross motor functions may improve to a similar extent with spontaneous and GM1-induced recovery from experimental parkinsonism, complex sensorimotor behavior recovers to different extents under the different recovery conditions. More complete behavioral recovery may depend upon at least a partial recovery of striatal dopaminergic terminals rather than neurochemical compensation.
给猫注射1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）会导致帕金森综合征，其特征为强直、运动不能、运动迟缓、对外界感觉刺激的反应降低以及黑质纹状体多巴胺耗竭。尽管纹状体的多巴胺能神经支配几乎没有恢复，但猫能自发恢复总体感觉运动功能。相比之下，给予GM1神经节苷脂可加速总体行为恢复，并使纹状体的多巴胺能神经支配增加。本研究探讨了这两种恢复情况是否具有不同程度的功能恢复特征。在MPTP暴露前，训练猫执行感觉运动够物任务，然后在自发恢复总体运动功能6周后或GM1治疗6周后，对该任务进行重新测试。两组的总体运动恢复情况相似。然而，自发恢复的猫在执行任务时存在显著困难，而接受GM1治疗的猫则表现正常。与自发恢复的猫相比，接受GM1治疗的猫纹状体[3H]麦角乙脲结合也显著增加。这些结果表明，虽然从实验性帕金森病中自发恢复和GM1诱导恢复时总体运动功能可能在相似程度上得到改善，但在不同的恢复条件下，复杂的感觉运动行为恢复程度不同。更完全的行为恢复可能取决于纹状体多巴胺能终末至少部分恢复，而非神经化学补偿。
