Okusaka T, Okada S, Ishii H, Ikeda M, Kosakamoto H, Yoshimori M
Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan.
Nutr Cancer. 1998;32(1):55-8. doi: 10.1080/01635589809514717.
Progressive weight loss and nutritional deterioration are commonly found in patients with advanced pancreatic cancer. There have been few studies of whether nutritional support improves survival for these patients. We retrospectively investigated the relationship between calorie intake and survival in 50 patients who died from cancer. The survival period was calculated from the day when their serum albumin level measured < 3.0 mg/dl. Total calorie intake was calculated on the basis of diet and parenteral nutrition for the week before the day when serum albumin levels fell to < 3.0 mg/dl. Patients were divided into a low- and a high-calorie intake group using the median of calorie intake per predictive basal metabolism. The survival period was significantly longer for the high- than for the low-calorie intake group (median 50 vs. 32 days, p = 0.02). We also investigated the relationships between calories of parenteral nutrition and survival. High-calorie parenteral nutrition subgroups tended to survive longer than low-calorie parenteral nutrition subgroups irrespective of enteral nutrition. Sufficient calorie intake may have the potential to prolong survival for patients with advanced pancreatic cancer.
进行性体重减轻和营养恶化在晚期胰腺癌患者中很常见。关于营养支持是否能改善这些患者的生存率，相关研究较少。我们回顾性调查了50例癌症死亡患者的热量摄入与生存率之间的关系。生存期从血清白蛋白水平测定<3.0mg/dl之日起计算。总热量摄入是根据血清白蛋白水平降至<3.0mg/dl前一周的饮食和肠外营养来计算的。根据预测基础代谢的热量摄入中位数，将患者分为低热量摄入组和高热量摄入组。高热量摄入组的生存期明显长于低热量摄入组（中位数分别为50天和32天，p=0.02）。我们还研究了肠外营养热量与生存率之间的关系。无论肠内营养情况如何，高热量肠外营养亚组的生存期往往比低热量肠外营养亚组更长。充足的热量摄入可能有延长晚期胰腺癌患者生存期的潜力。
