Highley J R, Esiri M M, McDonald B, Cortina-Borja M, Cooper S J, Herron B M, Crow T J
Department of Neuropathology, Radcliffe Infirmary, Oxford, UK.
Schizophr Res. 1998 Nov 9;34(1-2):13-25. doi: 10.1016/s0920-9964(98)00077-2.
In a post-mortem study of cerebral asymmetry in schizophrenia it was found that asymmetry of the length from the frontal pole to the central sulcus measured dorsally over the external surface of the brain on both hemispheres, showed a gender x diagnosis interaction (p = 0.002). Female controls had a left-greater-than-right asymmetry, and the male controls had a right-greater-than-left asymmetry. This pattern was reversed in schizophrenia. The converse effect was observed on a similar measure of the occipito-parietal lobes (p = 0.028). Significant changes were not seen in measures taken around the lateral surface of the hemispheres. Further, within the patient group, the frontal lobe asymmetry was related to age of onset such that leftward asymmetrical brains were associated with a later age of onset than rightward asymmetrical brains (p = 0.0463 for the females; p = 0.0162 for the males). The occipito-parietal asymmetry was not related to age of onset. We conclude that the asymmetry of the relative distribution of tissue between frontal and posterior regions of the hemispheres is altered in schizophrenia. The findings also suggest that there is an interaction between gender and cerebral asymmetry that is critical in determining age of onset.
在一项关于精神分裂症大脑不对称性的尸检研究中发现，在大脑两半球外表面背侧测量的从额极到中央沟的长度不对称性呈现出性别×诊断交互作用（p = 0.002）。女性对照组表现为左大于右的不对称性，而男性对照组表现为右大于左的不对称性。这种模式在精神分裂症患者中则相反。在枕顶叶的类似测量中也观察到了相反的效应（p = 0.028）。在半球侧面进行的测量未发现显著变化。此外，在患者组中，额叶不对称性与发病年龄相关，即左侧不对称的大脑与比右侧不对称大脑更晚的发病年龄相关（女性p = 0.0463；男性p = 0.0162）。枕顶叶不对称性与发病年龄无关。我们得出结论，精神分裂症患者大脑半球前后区域组织相对分布的不对称性发生了改变。研究结果还表明，性别与大脑不对称性之间存在交互作用，这在确定发病年龄方面至关重要。
