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钩状束的不对称性:对正常受试者和精神分裂症患者的尸检研究

Asymmetry of the uncinate fasciculus: a post-mortem study of normal subjects and patients with schizophrenia.

作者信息

Highley J Robin, Walker Mary A, Esiri Margaret M, Crow Timothy J, Harrison Paul J

机构信息

Schizophrenia Research Group, Department of Clinical Neurology (Neuropathology), Radcliffe Infirmary, Oxford, UK.

出版信息

Cereb Cortex. 2002 Nov;12(11):1218-24. doi: 10.1093/cercor/12.11.1218.

DOI:10.1093/cercor/12.11.1218
PMID:12379610
Abstract

The uncinate fasciculus interconnects the anterior temporal and inferior frontal lobes. The temporal lobes show a number of anatomical asymmetries, some of which are altered in schizophrenia. This study was performed to assess the size and symmetry of the uncinate fasciculus in normal subjects and in patients with the disorder. The area, fibre density and total fibre number of left and right uncinate fasciculi were estimated using stereological methods in 21 control subjects and 17 schizophrenics. The uncinate fasciculus was found to be asymmetrical in both sexes, being 27% larger and containing 33% more fibres in the right than the left hemisphere. Of the 25 brains from which both hemispheres were available, the size asymmetry was seen in 20 subjects and the greater number of fibres in 21 subjects. There was no significant effect of schizophrenia upon the uncinate fasiculus, nor interactions of diagnosis with side or sex. We conclude that the uncinate fasciculus is larger in the right hemisphere, perhaps indicating greater right-sided fronto-temporal connectivity. The unchanged size of the fasciculus in schizophrenia contrasts with commissural tracts, which are affected in this brain series in a sex-specific manner.

摘要

钩状束连接颞叶前部和额叶下部。颞叶存在一些解剖学上的不对称性,其中一些在精神分裂症中会发生改变。本研究旨在评估正常受试者和患有该疾病的患者中钩状束的大小和对称性。使用体视学方法估计了21名对照受试者和17名精神分裂症患者左右钩状束的面积、纤维密度和纤维总数。发现钩状束在两性中均不对称,右侧比左侧大27%,纤维数量多33%。在可获得双侧大脑的25个大脑中,20名受试者存在大小不对称,21名受试者存在纤维数量较多的情况。精神分裂症对钩状束没有显著影响,诊断与左右侧或性别的交互作用也不存在。我们得出结论,钩状束在右半球更大,这可能表明右侧额颞连接性更强。精神分裂症患者中钩状束大小未改变,这与连合束不同,在该脑系列中连合束以性别特异性方式受到影响。

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