Horn H, Maschler I
Steroids. 1976 Sep;28(3):405-9. doi: 10.1016/0039-128x(76)90049-0.
1,2-3H121-Deoxycortisol (1) 1,2-3H21-deoxycortisone and 1,2-3H-17OH-progesterone were incubated separately with dog adrenal microsomes. With substrates concentrations of 30 and 150 nmoles all the substrates were hydroxylated at C-21 to a similar extent. This result suggests that 21-deoxycortisol could be an intermediate in the biosynthesis of cortisol provided it is avilable in vivo.
将1,2 - ³H标记的11 - 脱氧皮质醇（1）、1,2 - ³H标记的11 - 脱氧皮质酮和1,2 - ³H标记的17α - 羟孕酮分别与犬肾上腺微粒体一起温育。在底物浓度为30和150纳摩尔时，所有底物在C - 21位的羟基化程度相似。该结果表明，如果11 - 脱氧皮质醇在体内可得，它可能是皮质醇生物合成的中间体。
