灌注犬肾上腺对C-11-氧化甾体和C-11-脱氧甾体的21-羟化作用。
21-Hydroxylation of C-11-oxygenated and C-11-deoxysteroids by perfused dog adrenals.
作者信息
Horn H, Halperin G, Weidenfeld J, Mordohovich D, Maschler I
出版信息
Steroids. 1977 Aug;30(2):165-7. doi: 10.1016/0039-128x(77)90078-2.
The left adrenal of two female dogs were perfused with either 3 muCi [4-14C]cpd. S (2) and 45 muCi [1, 2-3H] 21-deoxycortisone (Dog I), or with 1 muCi [4-14C] 17-hydroxyprogesterone and 65 muCi [1,2-3H] 21-deoxycortisone (Dog II). In Dog I, 40% of the perfused 21-deoxycortisone was converted to cortisone and 23% of cpd. S was converted to cortisol. In Dog II the percent conversion of 21-deoxycortisone to cortisone and of 17- hydroxyprogesterone to cortisol was 24% and 15% respectively. The results demonstrate that the dog adrenal has the capability of hydroxylating an 11-oxygenated steroid at C-21.
给两只雌性犬的左肾上腺分别灌注以下物质
3微居里的[4-¹⁴C]化合物S(2)和45微居里的[1,2-³H]21-脱氧皮质酮（犬I），或者1微居里的[4-¹⁴C]17-羟孕酮和65微居里的[1,2-³H]21-脱氧皮质酮（犬II）。在犬I中，灌注的21-脱氧皮质酮有40%转化为可的松，化合物S有23%转化为皮质醇。在犬II中，21-脱氧皮质酮转化为可的松的百分比以及17-羟孕酮转化为皮质醇的百分比分别为24%和15%。结果表明，犬肾上腺具有在C-21位羟基化11-氧化类固醇的能力。
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