Arutla S, Arra G S, Prabhakar C M, Krishna D R
Drug Metabolism Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, A.P., India.
Arzneimittelforschung. 1998 Oct;48(10):1024-7.
The effect of ofloxacin (CAS 82419-36-1), dapsone (CAS 80-08-0), rifampicin (CAS 13282-46-1) and clofazimine (CAS 2030-63-9) on the generation of superoxide anions was studied in vitro. The drugs were incubated with a superoxide generating system (photochemical reaction between riboflavin and dianisidine). The change in optical density was measured. The optical density was increased with dapsone and ofloxacin and decreased in presence of clofazimine and rifampicin. This result indicates that ofloxacin and dapsone have an antioxidant property, whereas clofazimine and rifampicin behave as pro-oxidants.
研究了氧氟沙星（CAS 82419-36-1）、氨苯砜（CAS 80-08-0）、利福平（CAS 13282-46-1）和氯法齐明（CAS 2030-63-9）对超氧阴离子生成的体外影响。将这些药物与超氧生成系统（核黄素和联茴香胺之间的光化学反应）一起孵育。测量光密度的变化。氨苯砜和氧氟沙星使光密度增加，而氯法齐明和利福平存在时光密度降低。该结果表明氧氟沙星和氨苯砜具有抗氧化特性，而氯法齐明和利福平表现为促氧化剂。
