Leroi I, Michalon M
Dalhousie University, Halifax, Nova Scotia.
Can J Psychiatry. 1998 Nov;43(9):933-40. doi: 10.1177/070674379804300909.
To review the clinical management of the psychiatric aspects of Huntington's disease (HD), namely the mood disorders, psychotic disorders, anxiety symptoms, sleep disorders, disorders of sexuality, and the behavioural changes of apathy, irritability, and aggression. Emphasis is on pharmacologic and psychotherapeutic intervention strategies. In addition, the role of psychiatric intervention in presymptomatic testing is explored.
English language literature on the pharmacologic and psychotherapeutic management of the psychiatric manifestations of HD between 1976 and 1996 was critically reviewed.
Few sound studies address the clinical management of the psychiatric aspects of HD; thus, only the broadest conclusions can be drawn. Pharmacologic strategies for the treatment of psychiatric aspects of HD were organized according to the therapeutic agent and class, and psychotherapeutic strategies were discussed.
The clinical management of the psychiatric manifestations of HD requires much more complete and systematic study before any definite conclusions as to efficacy of various approaches can be drawn.
回顾亨廷顿舞蹈症（HD）精神方面问题的临床管理，即情绪障碍、精神障碍、焦虑症状、睡眠障碍、性障碍以及冷漠、易怒和攻击行为等行为变化。重点是药物和心理治疗干预策略。此外，还探讨了精神科干预在症状前检测中的作用。
对1976年至1996年间关于HD精神症状的药物和心理治疗管理的英文文献进行了严格审查。
很少有可靠的研究涉及HD精神方面问题的临床管理；因此，只能得出最宽泛的结论。根据治疗药物和类别对HD精神方面问题的药物治疗策略进行了整理，并讨论了心理治疗策略。
在能够就各种方法的疗效得出任何明确结论之前，HD精神症状的临床管理需要更全面、系统的研究。
