Paulsen J S, Ready R E, Hamilton J M, Mega M S, Cummings J L
Department of Psychiatry, The University of Iowa, 2880 JPP, 200 Hawkins Drive, Iowa City, IA 52242, USA.
J Neurol Neurosurg Psychiatry. 2001 Sep;71(3):310-4. doi: 10.1136/jnnp.71.3.310.
Neuropsychiatric symptoms are common in Huntington's disease and have been considered its presenting manifestation. Research characterising these symptoms in Huntington's disease is variable, however, encumbered by limitations within and across studies. Gaining a better understanding of neuropsychiatric symptoms is essential, as these symptoms have implications for disease management, prognosis, and quality of life for patients and caregivers.
Fifty two patients with Huntington's disease were administered standardised measures of cognition, psychiatric symptoms, and motor abnormalities. Patient caregivers were administered the neuropsychiatric inventory.
Ninety eight per cent of the patients exhibited neuropsychiatric symptoms, the most prevalent being dysphoria, agitation, irritability, apathy, and anxiety. Symptoms ranged from mild to severe and were unrelated to dementia and chorea.
Neuropsychiatric symptoms are prevalent in Huntington's disease and are relatively independent of cognitive and motor aspects of the disease. Hypothesised links between neuropsychiatric symptoms of Huntington's disease and frontal-striatal circuitry were explored. Findings indicate that dimensional measures of neuropsychiatric symptoms are essential to capture the full range of pathology in Huntington's disease and are vital to include in a comprehensive assessment of the disease.
神经精神症状在亨廷顿舞蹈症中很常见，并被认为是其首发表现。然而，对亨廷顿舞蹈症中这些症状的研究具有变异性，受到研究内部和研究之间的局限性的阻碍。更好地理解神经精神症状至关重要，因为这些症状对疾病管理、预后以及患者和护理人员的生活质量都有影响。
对52名亨廷顿舞蹈症患者进行了认知、精神症状和运动异常的标准化测量。对患者的护理人员进行了神经精神症状量表评估。
98%的患者表现出神经精神症状，最常见的是烦躁不安、激动、易怒、冷漠和焦虑。症状从轻度到重度不等，与痴呆和舞蹈症无关。
神经精神症状在亨廷顿舞蹈症中很普遍，并且相对独立于该疾病的认知和运动方面。探讨了亨廷顿舞蹈症神经精神症状与额叶 - 纹状体回路之间的假设联系。研究结果表明，神经精神症状的维度测量对于全面了解亨廷顿舞蹈症的病理状况至关重要，并且对于该疾病的综合评估至关重要。
