Virag N, Vesin J M, Kappenberger L
Signal Processing Laboratory, Swiss Federal Institute of Technology, Lausanne, Switzerland.
Pacing Clin Electrophysiol. 1998 Nov;21(11 Pt 2):2366-71. doi: 10.1111/j.1540-8159.1998.tb01183.x.
Modern computer power allows development of models of the heart that may be helpful for the understanding of arrhythmia mechanisms if, based on realistic physiological parameters, such models can display phenomena difficult to study in nature. Therefore, a two-dimensional model of the cardiac tissue has been implemented, where the modeling of each cell is based on membrane ionic channels (Beeler-Reuter and Luo-Rudy models). In addition, an ECG was computed based on the ionic currents simulated. This model allows us to observe the propagation of the action potentials Vm across the cardiac tissue, the evolution of Vm for any of the cardiac cells, and the underlying ionic currents. The computation of the ECG makes it possible to relate this information with an often-used diagnostic tool. Simulations of normal and pathological phenomena such as functional and anatomic reentry have been performed. Our simulation results show that the applied computer model based on ionic currents seems accurate and realistic when compared with biological models and offers a new approach to study the origin, prevention, and termination of arrhythmias.
现代计算机的强大功能使得心脏模型得以开发，如果基于现实的生理参数，这类模型有助于理解心律失常机制，因为它们能够展现一些在自然状态下难以研究的现象。因此，我们构建了一个二维心脏组织模型，其中每个细胞的建模基于膜离子通道（比勒 - 罗伊特模型和罗 - 鲁迪模型）。此外，基于模拟的离子电流计算出了心电图。该模型使我们能够观察动作电位Vm在心脏组织中的传播、任何心脏细胞Vm的变化以及潜在的离子电流。心电图的计算使得将这些信息与常用的诊断工具联系起来成为可能。我们已经对正常和病理现象进行了模拟，如功能性和解剖性折返。我们的模拟结果表明，与生物模型相比，基于离子电流的应用计算机模型似乎准确且现实，为研究心律失常的起源、预防和终止提供了一种新方法。
