赞比亚急性呼吸道感染儿童的呼吸道合胞病毒感染
Respiratory syncytial virus infection in children with acute respiratory infections in Zambia.
作者信息
Saijo M, Terunuma H, Mizuta K, Mpabalwani E M, Monze M, Oshitani H, Luo N, Suzuki H, Numazaki Y
机构信息
Department of Microbiology and Pathology, University Teaching Hospital, Lusaka, Zambia.
出版信息
Epidemiol Infect. 1998 Oct;121(2):397-400. doi: 10.1017/s0950268898001228.
Epidemiological research on respiratory syncytial virus (RSV) infections in children was carried out at the Virology Laboratory, University Teaching Hospital (UTH), in Lusaka, Zambia, from January-December 1996. Specimens including 736 nasal washings and 2424 throat swabs were collected from children with acute respiratory infections (ARI) and tested for RSV by enzyme immunoassay and by virus isolation. RSV was isolated in 62 (4.1%) of 1496 throat swabs collected from March to September and was detected in 99 (16.3%) of 609 nasal washings from March to November. The average RSV isolation rate was 2.6% and the average RSV detection rate was 13.5%. The highest RSV isolation (8.1%) and detection (30.5%) rates were in June 1996. RSV antibody in the 278 serum specimens collected from Zambian children, who were hospitalized in the paediatric ward, UTH, was detected using a standard neutralization test. The antibody positive rate was 60-80% in children > 4 years. It is evident that RSV is one of the main causal agents of ARI in children in Zambia.
1996年1月至12月，在赞比亚卢萨卡大学教学医院（UTH）的病毒学实验室对儿童呼吸道合胞病毒（RSV）感染进行了流行病学研究。从患有急性呼吸道感染（ARI）的儿童中采集了包括736份洗鼻液和2424份咽拭子在内的标本，并通过酶免疫测定和病毒分离法检测RSV。在3月至9月采集的1496份咽拭子中，有62份（4.1%）分离出RSV；在3月至11月采集的609份洗鼻液中，有99份（16.3%）检测到RSV。RSV的平均分离率为2.6%，平均检测率为13.5%。1996年6月的RSV分离率（8.1%）和检测率（30.5%）最高。使用标准中和试验检测了从UTH儿科病房住院的赞比亚儿童采集的278份血清标本中的RSV抗体。4岁以上儿童的抗体阳性率为60%-80%。显然，RSV是赞比亚儿童ARI的主要致病因素之一。
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