干扰素抗性细胞亚系对双链RNA毒性作用的抗性增强。
Increased resistance of an interferon-resistant cell subline to the toxic effect of double-stranded RNA.
作者信息
Lackovic V, Borecký L
出版信息
Acta Virol. 1976 Aug;20(4):347-8.
PMID:9826
Abstract
The toxicity of double-stranded (ds) f2-phage RNA for interferon-treated L cells and an interferon-resistant subline of L cells (CVS cells) was compared. The interferon-resistant subline proved to be about 20 times more resistant to ds RNA than the parent L cells. The degree of toxicity of ds RNA was dependent on the concentration of interferon to which the cells were exposed.
摘要
比较了双链（ds）f2噬菌体RNA对经干扰素处理的L细胞和L细胞的干扰素抗性亚系（CVS细胞）的毒性。结果表明，该干扰素抗性亚系对ds RNA的抗性比亲代L细胞高约20倍。ds RNA的毒性程度取决于细胞所接触的干扰素浓度。
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