人类肥大细胞在暴露于革兰氏阴性菌和革兰氏阳性菌后的吞噬作用及肿瘤坏死因子α反应。
Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria.
作者信息
Arock M, Ross E, Lai-Kuen R, Averlant G, Gao Z, Abraham S N
机构信息
Departments of Cellular and Molecular Hematology, Faculty of Pharmacy, 75270 Paris Cedex 06, France.
出版信息
Infect Immun. 1998 Dec;66(12):6030-4. doi: 10.1128/IAI.66.12.6030-6034.1998.
Abstract
Recent studies have implicated rodent mast cells in the innate immune response to infectious bacteria. We report that cord blood-derived human mast cells (CBHMC) obtained from culture of cord blood progenitors phagocytozed and killed various gram-negative and gram-positive bacteria and simultaneously released considerable amounts of tumor necrosis factor alpha. Overall, the extent of the endocytic and exocytic response of CBHMC correlated with the number of adherent bacteria. Thus, human mast cells are intrinsically capable of mediating microbial recognition and of actively contributing to the host defense against bacteria.
摘要
最近的研究表明，啮齿动物肥大细胞参与了对感染性细菌的固有免疫反应。我们报告称，从脐血祖细胞培养物中获得的脐血来源的人肥大细胞（CBHMC）吞噬并杀死了各种革兰氏阴性菌和革兰氏阳性菌，同时释放了大量的肿瘤坏死因子α。总体而言，CBHMC的内吞和外排反应程度与黏附细菌的数量相关。因此，人肥大细胞本质上能够介导微生物识别，并积极参与宿主对细菌的防御。
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本文引用的文献
1
2
Evidence for direct interaction between mast cells and Leishmania parasites.
Parasite Immunol. 1997 Oct;19(10):475-83. doi: 10.1046/j.1365-3024.1997.d01-153.x.
3
Impaired mast cell-dependent natural immunity in complement C3-deficient mice.
Nature. 1997 Nov 13;390(6656):172-5. doi: 10.1038/36586.
4
The role of basophils and mast cells in acute and late reactions in the skin.
Allergy. 1997;52(34 Suppl):31-43. doi: 10.1111/j.1398-9995.1997.tb04809.x.
5
Role of C3a and C5a in the activation of mast cells.
Exp Clin Immunogenet. 1997;14(1):16-8.
6
Unravelling the mast cell dilemma: culprit or victim of its generosity?
Immunol Today. 1997 May;18(5):212-5. doi: 10.1016/s0167-5699(97)01034-7.
7
Molecular genetics and development of mast cells: implications for molecular medicine.
Mol Med Today. 1997 Mar;3(3):131-7. doi: 10.1016/S1357-4310(96)10061-7.
8
Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase.
J Leukoc Biol. 1997 Mar;61(3):233-45. doi: 10.1002/jlb.61.3.233.
9
The human mast cell.
J Allergy Clin Immunol. 1997 Feb;99(2):155-60. doi: 10.1016/s0091-6749(97)70089-7.
10
Human mast cell cytokines.
Clin Exp Allergy. 1996 Jan;26(1):13-9. doi: 10.1111/j.1365-2222.1996.tb00051.x.
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