水温对8-甲氧基补骨脂素浴用PUVA疗法中光致敏作用的影响。
Effects of water temperature on photosensitization in bath-PUVA therapy with 8-methoxypsoralen.
作者信息
Gruss C, Behrens S, von Kobyletzki G, Reuther T, Husebo L, Altmeyer P, Kerscher M
机构信息
Department of Dermatology, Ruhr-University of Bochum, Germany.
出版信息
Photodermatol Photoimmunol Photomed. 1998 Oct-Dec;14(5-6):145-7. doi: 10.1111/j.1600-0781.1998.tb00032.x.
The pharmacokinetic aspects of bath-PUVA are not completely clarified. Therefore, we determined the phototoxic response of human skin following psoralen baths at temperatures ranging from 32 degrees C to 42 degrees C (71.6-107.6 degrees F) and UVA doses ranging from 0.5 to 5.5 J/cm2. The highest therapeutical photosensitization (i.e., lowest minimal phototoxic dose) was assessed at temperatures of 37 degrees C (98.6 degrees F) and above. Photosensitization was significantly decreased at lower temperatures. These data indicate that a bath temperature of 37 degrees C (98.6 degrees F) should be used to gain optimal therapeutic efficiency in a clinical setting. Furthermore, in order to minimize the risk of adverse phototoxic effects in bath-PUVA, it is important to use a constant temperature during the psoralen bath.
水浴补骨脂素光化学疗法（bath-PUVA）的药代动力学方面尚未完全阐明。因此，我们测定了在32摄氏度至42摄氏度（71.6 - 107.6华氏度）的温度范围内进行补骨脂素浴后，以及在0.5至5.5 J/cm²的紫外线A（UVA）剂量下人体皮肤的光毒性反应。在37摄氏度（98.6华氏度）及以上的温度下评估出最高的治疗性光敏作用（即最低的最小光毒性剂量）。在较低温度下，光敏作用显著降低。这些数据表明，在临床环境中应使用37摄氏度（98.6华氏度）的水浴温度以获得最佳治疗效果。此外，为了将水浴补骨脂素光化学疗法中不良光毒性作用的风险降至最低，在补骨脂素浴期间保持恒定温度很重要。
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