Bray I C, Wright D E
School of Mathematics and Statistics, University of Plymouth, U.K.
Prenat Diagn. 1998 Oct;18(10):1045-54.
Recent publications concerning the prevalence of Down syndrome at times of chorionic villus sampling (CVS), amniocentesis and livebirth were reviewed with particular interest in estimates of spontaneous loss of Down syndrome fetuses during pregnancy. Data from several studies were combined to provide information on 258,206 pregnancies. A logistic regression was applied to provide new estimates and confidence intervals (CIs) for spontaneous loss rates between the time of CVS and livebirth (estimate = 39 per cent; 90 per cent CI 32 to 45 per cent), and the time of amniocentesis and livebirth (estimate = 12 per cent; 90 per cent CI 5 to 18 per cent).
近期有关绒毛取样（CVS）、羊膜穿刺术时唐氏综合征的患病率以及活产情况的出版物受到了审查，特别关注孕期唐氏综合征胎儿自然丢失率的估计。对多项研究的数据进行了汇总，以提供有关258,206例妊娠的信息。应用逻辑回归分析来提供绒毛取样至活产期间（估计值 = 39%；90%置信区间为32%至45%）以及羊膜穿刺术至活产期间（估计值 = 12%；90%置信区间为5%至18%）自然丢失率的新估计值和置信区间（CIs）。
