Pierson S H
Heather Hill Rehabilitation Hospital, Chardon, OH 44024, USA.
Muscle Nerve Suppl. 1997;6:S36-60.
Development of validated and reliable outcome measures for spasticity rehabilitation has been hampered by the difficulty of quantifying functionally important parameters such as pain, ease of care, and mobility. Nonetheless, a combination of measures designed to assess technical and functional outcomes, patient satisfaction, and the cost effectiveness of treatment can be used together to evaluate status and track change in spasticity management, including treatment programs involving botulinum toxin. While double-blind, placebo-controlled studies remain the gold standard for clinical testing, the single-subject design is a useful alternative in many treatment protocols. Because no single tool can measure the many types of changes possible with treatment, the choice of assessment tools must be based on the functional changes expected from the treatment. A wide range of assessment tools are critically reviewed for their sensitivity, reliability, validity, and ease of administration.
痉挛性麻痹康复有效且可靠的结果测量方法的开发，因难以量化疼痛、护理便利性和活动能力等功能上重要的参数而受阻。尽管如此，旨在评估技术和功能结果、患者满意度以及治疗成本效益的一系列测量方法可以一起用于评估痉挛性麻痹管理的状态并追踪其变化，包括涉及肉毒杆菌毒素的治疗方案。虽然双盲、安慰剂对照研究仍然是临床试验的金标准，但单受试者设计在许多治疗方案中是一种有用的替代方法。由于没有单一工具能够测量治疗可能带来的多种类型的变化，评估工具的选择必须基于治疗预期产生的功能变化。对一系列评估工具的敏感性、可靠性、有效性和易用性进行了严格审查。
