Cathébras P, Brouqui P, Philippe P, Raoult D, Rousset H
Service de médecine interne, CHU Nord, Saint-Etienne, France.
Rev Med Interne. 1998 Oct;19(10):740-2. doi: 10.1016/s0248-8663(98)80711-x.
The most frequent clinical expression of chronic Q fever is culture-negative endocarditis. Other localizations are rare.
We report a documented case of chronic Q fever that occurred in a 47-year-old immunocompetent man and was associated with spleen abscess, in the absence of detectable endocarditis. The spleen abscess was a complication of either a preexisting cyst or a calcified hematoma. Splenic infection with Coxiella burnetii was documented with cultures, polymerase chain reaction and immunohistochemistry. The outcome was favorable after splenectomy and a 21-month antibiotherapy.
Chronic Q fever may develop in the absence of endocarditis, when a preexisting vascular lesion such as aortic aneurysm exists. A splenic cyst may have played a similar role for this patient.
慢性Q热最常见的临床表现是血培养阴性的心内膜炎。其他部位感染较为罕见。
我们报告一例确诊的慢性Q热病例,发生在一名47岁免疫功能正常的男性身上,该病例与脾脓肿相关,且未检测到心内膜炎。脾脓肿是先前存在的囊肿或钙化血肿的并发症。通过培养、聚合酶链反应和免疫组织化学证实了脾脏感染伯氏考克斯体。脾切除术后联合21个月的抗生素治疗,预后良好。
当存在如主动脉瘤等先前存在的血管病变时,慢性Q热可能在无心内膜炎的情况下发生。脾囊肿可能对该患者起到了类似作用。