Burek J D, van der Kogel A J, Hollander C F
Vet Pathol. 1976;13(5):321-31. doi: 10.1177/030098587601300501.
Spontaneous paresis and paralysis associated with degenerative spinal cord and spinal nerve root lesions occurred in three strains of rats used in studies of aging. Focal or segmental spinal cord lesions had mild to severe demyelination, loss of nerve axons, and lipid-filled gitter cells. The lesions were limited to the white matter and were most severe in the lateral and ventral funiculi. The nerve roots had cholesterol clefts, focal hemorrhage, and demyelination. Atrophy of the skeletal muscle probably was secondary to the cord lesions. Vertebral lesions that involved the spinal canal and vascular blood flow were found, which may explain pathogenesis.
在衰老研究中使用的三个品系的大鼠出现了与脊髓和脊神经根退行性病变相关的自发性轻瘫和瘫痪。局灶性或节段性脊髓病变有轻度至重度脱髓鞘、神经轴突丧失和充满脂质的格子细胞。病变局限于白质，在外侧和腹侧索最为严重。神经根有胆固醇裂隙、局灶性出血和脱髓鞘。骨骼肌萎缩可能继发于脊髓病变。发现了累及椎管和血管血流的椎体病变，这可能解释其发病机制。
