van der Kogel A J
Acta Neuropathol. 1977 Aug 16;39(2):139-45. doi: 10.1007/BF00703320.
Three-month-old WAG/Rij rats were irradiated with 300 kV X-rays on the lumbar region of the spinal column with doses below the level for causing paralysis due to radiation radiculomyelopathy. 8--9 months after irradiation, degeneration of predominantly the ventral nerve roots of the cauda equina was boserved. Three stages were distinguishable: I) Demyelination and proliferation of Schwann cells; II) Local swelling of ventral nerve roots, with concentric layers of Schwann cells resembling hypertrophic neuropathy; III) Malignant Schwannoma, invading roots and spinal cord. It is concluded that the degenerative and proliferative lesions represent a continuous series of stages of slowly progressive lesions. The ventral nerve root degeneration (1st stage) is similar to that observed in aging, unirradiated rats, normally developing at the age of 18--20 months.
对3个月大的WAG/Rij大鼠的脊柱腰部区域进行300 kV X射线照射，照射剂量低于因放射性神经根脊髓病导致瘫痪的水平。照射后8 - 9个月，观察到主要是马尾神经腹侧神经根发生退变。可区分出三个阶段：I）脱髓鞘和施万细胞增殖；II）腹侧神经根局部肿胀，有类似肥厚性神经病的施万细胞同心层；III）恶性施万细胞瘤，侵犯神经根和脊髓。得出的结论是，退行性和增殖性病变代表了一系列缓慢进展性病变的连续阶段。腹侧神经根退变（第一阶段）与在未照射的老龄大鼠中观察到的情况相似，老龄大鼠通常在18 - 20个月龄时出现这种情况。
