Gorno-Tempini M L, Price C J, Josephs O, Vandenberghe R, Cappa S F, Kapur N, Frackowiak R S
Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK.
Brain. 1998 Nov;121 (Pt 11):2103-18. doi: 10.1093/brain/121.11.2103.
This PET study has revealed the neural system involved in implicit face, proper-name and object name processing during an explicit visual 'same' versus 'different' matching task. Within the identified system, some areas were equally active irrespective of modality (faces or names) or type of stimuli (famous and non-famous) while other areas exhibited differential effects. Our findings support the hypothesis that faces and names involve differential pre-semantic processing prior to accessing a common neural system of stored knowledge of personal identity which overlaps with the one associated with object knowledge. The areas specialized for the perceptual analysis of faces (irrespective of whether they are famous or non-famous) are the right lingual and bilateral fusiform gyri, while the areas specialized for famous stimuli (irrespective of whether they are faces or names) spread from the left anterior temporal to the left temporoparietal regions. One specific area, the more lateral portion of the left anterior middle temporal gyrus, showed increased activation for famous faces relative to famous proper names and for famous proper names relative to common names. The differential responsiveness of this region when processing familiar people suggests functional segregation of either personal attributes or, more likely, the demands placed on processes that retrieve stored knowledge when stimuli have highly similar visual features but unique semantic associations.
这项正电子发射断层扫描（PET）研究揭示了在明确的视觉“相同”与“不同”匹配任务中，参与隐性面孔、专有名词和物体名称处理的神经系统。在已确定的系统中，一些区域无论模态（面孔或名称）或刺激类型（著名和非著名）如何，都同样活跃，而其他区域则表现出不同的效应。我们的研究结果支持这样一种假设，即面孔和名称在进入一个存储个人身份知识的共同神经系统之前，涉及不同的语义前处理，该系统与与物体知识相关的系统重叠。专门用于面孔感知分析的区域（无论它们是著名的还是非著名的）是右侧舌回和双侧梭状回，而专门用于著名刺激的区域（无论它们是面孔还是名称）从左前颞叶延伸到左颞顶叶区域。一个特定区域，即左前颞中回的更外侧部分，相对于著名专有名词，对著名面孔的激活增加，相对于普通名词，对著名专有名词的激活增加。该区域在处理熟悉的人时的不同反应表明，要么是个人属性的功能分离，要么更有可能是当刺激具有高度相似的视觉特征但具有独特语义关联时，对检索存储知识的过程所提出的要求。
