HOMSTRAD：同源家族蛋白质结构比对数据库。
HOMSTRAD: a database of protein structure alignments for homologous families.
作者信息
Mizuguchi K, Deane C M, Blundell T L, Overington J P
机构信息
Department of Biochemistry, University of Cambridge, United Kingdom.
出版信息
Protein Sci. 1998 Nov;7(11):2469-71. doi: 10.1002/pro.5560071126.
Abstract
We describe a database of protein structure alignments for homologous families. The database HOMSTRAD presently contains 130 protein families and 590 aligned structures, which have been selected on the basis of quality of the X-ray analysis and accuracy of the structure. For each family, the database provides a structure-based alignment derived using COMPARER and annotated with JOY in a special format that represents the local structural environment of each amino acid residue. HOMSTRAD also provides a set of superposed atomic coordinates obtained using MNYFIT, which can be viewed with a graphical user interface or used for comparative modeling studies. The database is freely available on the World Wide Web at: http://www-cryst.bioc.cam. ac.uk/-homstrad/, with search facilities and links to other databases.
摘要
我们描述了一个用于同源蛋白家族的蛋白质结构比对数据库。目前，HOMSTRAD数据库包含130个蛋白质家族和590个比对结构，这些都是根据X射线分析的质量和结构的准确性挑选出来的。对于每个家族，该数据库提供了一个基于结构的比对，它是使用COMPARER推导出来的，并以一种特殊格式用JOY注释，该格式代表了每个氨基酸残基的局部结构环境。HOMSTRAD还提供了一组使用MNYFIT获得的叠加原子坐标，这些坐标可以通过图形用户界面查看，也可用于比较建模研究。该数据库可在万维网上免费获取，网址为：http://www-cryst.bioc.cam.ac.uk/-homstrad/，并提供搜索功能以及与其他数据库的链接。
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