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JOY：蛋白质序列-结构表示与分析

JOY: protein sequence-structure representation and analysis.

作者信息

Mizuguchi K, Deane C M, Blundell T L, Johnson M S, Overington J P

机构信息

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.

出版信息

Bioinformatics. 1998;14(7):617-23. doi: 10.1093/bioinformatics/14.7.617.

DOI:10.1093/bioinformatics/14.7.617
PMID:9730927
Abstract

MOTIVATION

JOY is a program to annotate protein sequence alignments with three-dimensional (3D) structural features. It was developed to display 3D structural information in a sequence alignment and to help understand the conservation of amino acids in their specific local environments.

RESULTS

: The JOY representation now constitutes an essential part of the two databases of protein structure alignments: HOMSTRAD (http://www-cryst.bioc.cam.ac.uk/homstrad ) and CAMPASS (http://www-cryst.bioc.cam.ac. uk/campass). It has also been successfully used for identifying distant evolutionary relationships.

AVAILABILITY

The program can be obtained via anonymous ftp from torsa.bioc.cam.ac.uk from the directory /pub/joy/. The address for the JOY server is http://www-cryst.bioc.cam.ac.uk/cgi-bin/joy.cgi.

CONTACT

kenji@cryst.bioc.cam.ac.uk

摘要

动机

JOY是一个用于用三维（3D）结构特征注释蛋白质序列比对的程序。它的开发目的是在序列比对中展示3D结构信息，并帮助理解氨基酸在其特定局部环境中的保守性。

结果

JOY表示法现在构成了两个蛋白质结构比对数据库的重要组成部分：HOMSTRAD（http://www-cryst.bioc.cam.ac.uk/homstrad ）和CAMPASS（http://www-cryst.bioc.cam.ac.uk/campass）。它也已成功用于识别远缘进化关系。

可用性

该程序可通过匿名ftp从torsa.bioc.cam.ac.uk的/pub/joy/目录获取。JOY服务器的地址是http://www-cryst.bioc.cam.ac.uk/cgi-bin/joy.cgi。

联系方式

kenji@cryst.bioc.cam.ac.uk

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JOY: protein sequence-structure representation and analysis.JOY：蛋白质序列-结构表示与分析
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