将细胞间黏附分子家族的神经元成员ICAM-5（端脑糖蛋白）基因定位到人类染色体19p13.2上细胞间黏附分子-1和细胞间黏附分子-3之间的位置。

Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2.

作者信息

Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin W M

机构信息

ICOS Corporation, Bothell, Washington, 98021, USA.

出版信息

Genomics. 1998 Dec 1;54(2):328-30. doi: 10.1006/geno.1998.5565.

DOI:10.1006/geno.1998.5565

PMID:9828136

Abstract

Intercellular adhesion molecule 5 (ICAM-5, telencephalin) is a cell adhesion molecule expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. Antibody studies in rodents and rabbits have demonstrated expression of this molecule on the cell body and dendrites of these neurons. We have examined the expression pattern in human brain by Northern blot analysis of 16 human brain segments. This analysis has confirmed the unique expression pattern of this ICAM in human. In addition, we report the mapping of the human ICAM-5 gene to an 80-kb region on chromosome 19p13.2 that also contains ICAM-1 and ICAM-3.

摘要

细胞间黏附分子5（ICAM - 5，端脑糖蛋白）是一种在哺乳动物大脑最前端部分即端脑中的神经元上表达的细胞黏附分子。对啮齿动物和兔子的抗体研究表明，该分子在这些神经元的细胞体和树突上表达。我们通过对16个人脑切片进行Northern印迹分析，研究了其在人脑中的表达模式。该分析证实了这种ICAM在人类中的独特表达模式。此外，我们报告了人类ICAM - 5基因定位于19号染色体p13.2上一个80kb的区域，该区域还包含ICAM - 1和ICAM - 3。