Kronenberg A, Krähenbühl S, Zimmermann A, Streuli R
Medizinische Klinik, Regionalspital Langenthal.
Praxis (Bern 1994). 1998 Oct 7;87(41):1356-60.
A 64 year old patient developed severe hepatocellular damage with jaundice and coagulopathy during ingestion of a combination of paracetamol and chlorzoxazone in therapeutic dosage. The risk factors for the development of liver cell necrosis following ingestion of paracetamol in therapeutic dosage are discussed. In particular in patients with risk factors (e.g. alcoholics and patients with heart failure) paracetamol-induced liver failure has to be considered in the presence of high transaminases, even when paracetamol was ingested in therapeutic dosage. Chlorzoxazone itself rarely can induce an idiosyncratic hepatocellular damage.
一名64岁患者在服用治疗剂量的对乙酰氨基酚和氯唑沙宗组合药物期间出现了伴有黄疸和凝血功能障碍的严重肝细胞损伤。讨论了服用治疗剂量对乙酰氨基酚后发生肝细胞坏死的危险因素。特别是对于有危险因素的患者（如酗酒者和心力衰竭患者），即使对乙酰氨基酚是按治疗剂量服用的，当转氨酶升高时也必须考虑对乙酰氨基酚引起的肝衰竭。氯唑沙宗本身很少能引起特异质性肝细胞损伤。
