甲硫氨酸通过一条依赖于ste11的信号通路诱导裂殖酵母粟酒裂殖酵母的性发育。
Methionine induces sexual development in the fission yeast Schizosaccharomyces pombe via an ste11-dependent signalling pathway.
作者信息
Schweingruber A M, Hilti N, Edenharter E, Schweingruber M E
机构信息
Institute of General Microbiology, University of Bern, CH-3012 Bern, Switzerland.
出版信息
J Bacteriol. 1998 Dec;180(23):6338-41. doi: 10.1128/JB.180.23.6338-6341.1998.
Abstract
Methionine added to minimal medium overcomes the repressing effects of ammonium and cyclic AMP (cAMP) on sexual development and efficiently induces mating and sporulation in homothallic strains of Schizosaccharomyces pombe. In heterothallic strains it induces G1 arrest when cells enter stationary phase. We show that methionine reduces the intracellular cAMP pool and induces the expression of at least two cAMP-repressible genes, including fbp1 and ste11. The easiest interpretation of the results is that methionine induces sexual development via a cAMP-dependent ste11 signalling pathway.
摘要
在基本培养基中添加甲硫氨酸可克服铵和环磷酸腺苷（cAMP）对粟酒裂殖酵母同宗配合菌株有性发育的抑制作用，并有效诱导其交配和孢子形成。在异宗配合菌株中，当细胞进入稳定期时，甲硫氨酸会诱导G1期停滞。我们发现，甲硫氨酸可减少细胞内cAMP池，并诱导至少两个cAMP抑制基因的表达，包括fbp1和ste11。对这些结果最简单的解释是，甲硫氨酸通过cAMP依赖的ste11信号通路诱导有性发育。
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