Almar M, Otero L, Santos C, González Gallego J
Department of Physiology, Pharmacology and Toxicology, University of León, Spain.
J Environ Sci Health B. 1998 Nov;33(6):769-83. doi: 10.1080/03601239809373177.
Glutathione content and glutathione-dependent enzymes were measured in the liver of two fish species, gudgeon (Gobio gobio) and roach (Rutilus arcasii), from the river Bernesga (Spain) caught downstream and upstream of the waste site of several chemical industries. Animals from contaminated sites display a reduced glutathione concentration and a tendency to the decrease of glutathione S-transferase activity. Glutathione peroxidase activity was significantly elevated only in the liver of Gobio gobio and glutathione reductase activity in that of Rutilus arcasii. Our data indicate that the glutathione system constitutes a sensitive biochemical indicator of chemical pollution. Relative changes of glutathione and glutathione-dependent enzymes in both fish species suggest a different susceptibility to toxins.
在西班牙贝内斯加河捕获的底栖鲤科小鱼（Gobio gobio）和拟赤梢鱼（Rutilus arcasii）这两种鱼类的肝脏中，测定了谷胱甘肽含量和谷胱甘肽依赖性酶。这些鱼分别来自几个化学工业废物处理场下游和上游的区域。来自受污染区域的动物体内谷胱甘肽浓度降低，谷胱甘肽S-转移酶活性有下降趋势。仅在底栖鲤科小鱼的肝脏中谷胱甘肽过氧化物酶活性显著升高，而在拟赤梢鱼的肝脏中谷胱甘肽还原酶活性显著升高。我们的数据表明，谷胱甘肽系统是化学污染的一个敏感生化指标。两种鱼类中谷胱甘肽及谷胱甘肽依赖性酶的相对变化表明它们对毒素的敏感性不同。
