Fawcett J P, Brooke M, Beresford C H
School of Pharmacy, University of Otago, Dunedin.
N Z Med J. 1998 Oct 23;111(1076):400-2.
To determine iron status in a longitudinal study of New Zealanders, the Dunedin Multidisciplinary Health and Development Study (DMHDS), at ages 11 (1983-4) and 21 (1993-4).
Red cell variables were measured in 553 (298 males, 255 females) and 784 (413 males, 371 females) members of the DMHDS at ages 11 and 21, respectively. A total of 456 (259 males, 197 females) members were tested at both ages. Serum ferritin was measured at age 21 only.
The prevalence of anaemia in females (haemoglobin < 120 g/L) increased from 3.1% at age 11 to 5.8% at age 21 (pregnant women excluded). There was a significant association between low haemoglobin at age 11 and low haemoglobin at age 21. In males, prevalence of anaemia decreased from 2.3% at age 11 to 0.97% (haemoglobin < 130 g/L) at age 21. The prevalence of iron deficiency (ferritin < 12 ng/mL) at age 21 was 0.24% in men and 6.7% in women. The prevalence of iron deficiency with anaemia at age 21 was zero in men and 2.2% in women.
The prevalences of anaemia and iron deficiency in the DMHDS appear to be low by comparison with similar populations in other countries. Anaemia appears to be a stable trait in young women and screening may be useful for its early detection.
在一项针对新西兰人的纵向研究——达尼丁多学科健康与发展研究（DMHDS）中，确定11岁（1983 - 1984年）和21岁（1993 - 1994年）时的铁状态。
分别在11岁和21岁时，对DMHDS的553名成员（298名男性，255名女性）和784名成员（413名男性，371名女性）测量红细胞变量。共有456名成员（259名男性，197名女性）在两个年龄段都进行了检测。仅在21岁时测量血清铁蛋白。
女性贫血患病率（血红蛋白<120 g/L）（不包括孕妇）从11岁时的3.1%升至21岁时的5.8%。11岁时血红蛋白低与21岁时血红蛋白低之间存在显著关联。在男性中，贫血患病率从11岁时的2.3%降至21岁时的0.97%（血红蛋白<130 g/L）。21岁时男性缺铁（铁蛋白<12 ng/mL）患病率为0.24%，女性为6.7%。21岁时缺铁伴贫血的患病率男性为零，女性为2.2%。
与其他国家的类似人群相比，DMHDS中的贫血和缺铁患病率似乎较低。贫血在年轻女性中似乎是一种稳定的特征，筛查可能有助于早期发现。
